20S Proteasome α2 Antibody (B-5): sc-166512

20S Proteasome α2 Antibody (B-5) is a mouse monoclonal IgG1 antibody that detects 20S Proteasome α2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). 20S Proteasome α2 is a crucial component of the 26S proteasome, which plays a vital role in maintaining cellular homeostasis by degrading unnecessary or damaged proteins through proteolysis. This process is essential for regulating various cellular functions, including cell cycle, signal transduction, and response to oxidative stress. The 20S core particle, which houses catalytic activity, is composed of multiple subunits forming a cylindrical structure, allowing selective entry of substrates while preventing unregulated access. α subunits serve as structural components, creating a barrier that ensures only properly tagged proteins are processed, while β subunits are responsible for proteolytic activity that cleaves target proteins into peptides. Precise regulation of this protein complex is critical, as dysregulation can lead to various diseases, including cancer and neurodegenerative disorders. anti-20S Proteasome α2 antibody (B-5) is an invaluable tool for researchers studying proteasome function and its implications in health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

20S Proteasome α2 Antibody (B-5) References:

1. Complement component C3 production in IL-1beta-stimulated human intestinal epithelial cells is blocked by NF-kappaB inhibitors and by transfection with ser 32/36 mutant IkappaBalpha.  |  Moon, MR., et al. 1999. J Surg Res. 82: 48-55. PMID: 10068525
2. Physical mapping of four porcine 20S proteasome core complex genes (PSMA1, PSMA2, PSMA3 and PSMA6).  |  Wu, X., et al. 2005. Cytogenet Genome Res. 108: 363. PMID: 15628037
3. Intergenic region between TATA-box binding protein and proteasome subunit C3 genes of Medaka function as the bidirectional promoter in vitro and in vivo.  |  Fujimori, KE., et al. 2012. Gene. 511: 177-86. PMID: 23026219
4. Molecular cloning of cDNA for proteasomes from rat liver: primary structure of component C3 with a possible tyrosine phosphorylation site.  |  Tanaka, K., et al. 1990. Biochemistry. 29: 3777-85. PMID: 2340272
5. Natural alleles of a proteasome α2 subunit gene contribute to thermotolerance and adaptation of African rice.  |  Li, XM., et al. 2015. Nat Genet. 47: 827-33. PMID: 25985140
6. Involvement of ALAD-20S Proteasome Complexes in Ubiquitination and Acetylation of Proteasomal α2 Subunits.  |  Schmitt, SM., et al. 2016. J Cell Biochem. 117: 144-51. PMID: 26084403
7. PAN3-PSMA2 fusion resulting from a novel t(7;13)(p14;q12) chromosome translocation in a myelodysplastic syndrome that evolved into acute myeloid leukemia.  |  Panagopoulos, I., et al. 2018. Exp Hematol Oncol. 7: 7. PMID: 29560286
8. New Peptide-Based Pharmacophore Activates 20S Proteasome.  |  Osmulski, PA., et al. 2020. Molecules. 25: PMID: 32235805
9. A Role for the Proteasome Alpha2 Subunit N-Tail in Substrate Processing.  |  Sahu, I., et al. 2023. Biomolecules. 13: PMID: 36979414
10. PSMA2 promotes chemo- and radioresistance of oral squamous cell carcinoma by modulating mitophagy pathway.  |  Wang, CI., et al. 2025. Cell Death Discov. 11: 2. PMID: 39794329

The preferred 20S Proteasome α2 antibody is 20S Proteasome α2 Antibody (B-4): sc-377148.