SH-PTP2 Antibody (B-1): sc-7384
- SH-PTP2 Antibody (B-1) is a mouse monoclonal IgG1 κ SH-PTP2 antibody, cited in 124 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 580-597 at the C-terminus of SH-PTP2 of human origin
- SH-PTP2 Antibody (B-1) is recommended for detection of SH-PTP2 of mouse, rat, human and origin by WB, IP, IF, IHC(P), FCM and ELISA; also reactive with additional species, including equine and avian
- Anti-SH-PTP2 Antibody (B-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for SH-PTP2 Antibody (B-1) for WB and IHC(P) applications. These reagents are now offered in bundles with SH-PTP2 Antibody (B-1) (see ordering information below).
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SH-PTP2 Antibody (B-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects the SH-PTP2 protein of mouse, rat, and human origin by WB, IP, IF, IHCP, FCM, and ELISA. SH-PTP2 Antibody (B-1) is available in both non-conjugated and various conjugated forms, including agarose, HRP, PE, FITC, and multiple Alexa Fluor® conjugates. SH-PTP2 protein, also known as PTPN11 or protein tyrosine phosphatase non-receptor type 11, plays a crucial role in cellular signaling by regulating the phosphorylation state of tyrosine residues on proteins, which is essential for controlling various cellular processes such as growth, differentiation, and metabolism. Located primarily in the cytoplasm, SH-PTP2 interacts with a variety of signaling molecules, including growth factor receptors and other phosphotyrosine-containing proteins, thereby influencing pathways that are vital for cellular responses to external stimuli. The importance of SH-PTP2 is underscored by its involvement in several diseases, including cancer, where dysregulation of its activity can lead to aberrant signaling and tumor progression. With its ability to modulate key signaling pathways, SH-PTP2 serves as a significant target for therapeutic intervention and research into cellular mechanisms.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SH-PTP2 Antibody (B-1) References:
- Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew. | Freeman, RM., et al. 1992. Proc Natl Acad Sci U S A. 89: 11239-43. PMID: 1280823
- Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences. | Matthews, RJ., et al. 1992. Mol Cell Biol. 12: 2396-405. PMID: 1373816
- A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases. | Shen, SH., et al. 1991. Nature. 352: 736-9. PMID: 1652101
- Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13. | Yi, TL., et al. 1992. Mol Cell Biol. 12: 836-46. PMID: 1732748
- Isolation of a src homology 2-containing tyrosine phosphatase. | Plutzky, J., et al. 1992. Proc Natl Acad Sci U S A. 89: 1123-7. PMID: 1736296
- Cloning of a cDNA for a major human protein-tyrosine-phosphatase. | Chernoff, J., et al. 1990. Proc Natl Acad Sci U S A. 87: 2735-9. PMID: 2157211
- Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation. | Vogel, W., et al. 1993. Science. 259: 1611-4. PMID: 7681217
- SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. | Feng, GS., et al. 1993. Science. 259: 1607-11. PMID: 8096088
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SH-PTP2 Antibody (B-1) | sc-7384 | 200 µg/ml | $322.00 | |||
SH-PTP2 Antibody (B-1): m-IgG Fc BP-HRP Bundle | sc-528180 | 200 µg Ab; 10 µg BP | $361.00 | |||
SH-PTP2 Antibody (B-1): m-IgGκ BP-HRP Bundle | sc-520499 | 200 µg Ab, 40 µg BP | $361.00 | |||
SH-PTP2 Antibody (B-1): m-IgG1 BP-HRP Bundle | sc-542805 | 200 µg Ab; 20 µg BP | $361.00 | |||
SH-PTP2 Antibody (B-1) AC | sc-7384 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SH-PTP2 Antibody (B-1) HRP | sc-7384 HRP | 200 µg/ml | $322.00 | |||
SH-PTP2 Antibody (B-1) FITC | sc-7384 FITC | 200 µg/ml | $336.00 | |||
SH-PTP2 Antibody (B-1) PE | sc-7384 PE | 200 µg/ml | $349.00 | |||
SH-PTP2 Antibody (B-1) Alexa Fluor® 488 | sc-7384 AF488 | 200 µg/ml | $364.00 | |||
SH-PTP2 Antibody (B-1) Alexa Fluor® 546 | sc-7384 AF546 | 200 µg/ml | $364.00 | |||
SH-PTP2 Antibody (B-1) Alexa Fluor® 594 | sc-7384 AF594 | 200 µg/ml | $364.00 | |||
SH-PTP2 Antibody (B-1) Alexa Fluor® 647 | sc-7384 AF647 | 200 µg/ml | $364.00 | |||
SH-PTP2 Antibody (B-1) Alexa Fluor® 680 | sc-7384 AF680 | 200 µg/ml | $364.00 | |||
SH-PTP2 Antibody (B-1) Alexa Fluor® 790 | sc-7384 AF790 | 200 µg/ml | $364.00 | |||
SH-PTP2 (B-1) Neutralizing Peptide | sc-7384 P | 100 µg/0.5 ml | $69.00 |