Date published: 2025-10-25

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SH-PTP2 Inhibitors

SH-PTP2, also commonly known as Src homology 2 domain-containing protein tyrosine phosphatase-2 (SHP-2), is a non-receptor protein tyrosine phosphatase that plays a critical role in numerous cellular signaling pathways. It is characterized by its unique structure, which includes two Src homology 2 (SH2) domains followed by a protein tyrosine phosphatase domain. The SH2 domains facilitate its interaction with other proteins, particularly those that have undergone tyrosine phosphorylation. Upon binding to its target molecules, SH-PTP2 undergoes a conformational change that activates its phosphatase activity, allowing it to dephosphorylate and regulate the function of its substrate proteins. Through these actions, SH-PTP2 impacts a variety of cellular processes, including cell growth, differentiation, migration, and survival. SH-PTP2 inhibitors are chemical entities designed to selectively hinder the activity of SH-PTP2. These inhibitors typically work by binding to the protein's active site or interfering with its interaction domains, thereby preventing SH-PTP2 from carrying out its phosphatase function or from associating with its target molecules.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

NSC 87877

56990-57-9sc-204139
50 mg
$134.00
12
(1)

NSC-87877 is a selective inhibitor of SHP-2 and can decrease its phosphatase activity, potentially reducing its expression.

PTP Inhibitor IV

329317-98-8sc-222225
10 mg
$173.00
4
(1)

PTP Inhibitor IV functions as a potent inhibitor of SH-PTP2, characterized by its ability to engage in specific hydrophobic interactions with the enzyme's active site. The presence of unique functional groups allows for enhanced π-π stacking and van der Waals forces, which stabilize the enzyme-inhibitor complex. This compound exhibits a distinct kinetic profile, influencing the rate of enzymatic reactions and altering the dynamics of cellular signaling cascades.

PTP Inhibitor V, PHPS1

314291-83-3sc-222226
10 mg
$243.00
12
(1)

PHPS1 is a selective inhibitor of SHP-2 and might reduce its activity and expression in cells.

PHPS1 sodium salt

314291-83-3 (free acid)sc-253272
5 mg
$209.00
(1)

PHPS1 is a selective inhibitor of SHP-2 and might reduce its activity and expression in cells.

Sodium stibogluconate

16037-91-5sc-202815
1 g
$184.00
6
(2)

This compound inhibits SHP-1 and SHP-2 activities and can potentially reduce SHP-2 levels in cells.

Sodium Orthovanadate

13721-39-6sc-3540
sc-3540B
sc-3540A
5 g
10 g
50 g
$45.00
$56.00
$183.00
142
(4)

It is a broad-spectrum phosphatase inhibitor that can inhibit SHP-2 activity and potentially affect its expression.

AG 1024

65678-07-1sc-205907
1 mg
$105.00
22
(1)

AG-1024 is an IGF-1R inhibitor and can indirectly reduce SHP-2 activity and expression.

Berberine

2086-83-1sc-507337
250 mg
$90.00
1
(0)

Berberine is an SHP-2 inhibitor that can decrease the activity and potentially the expression of SHP-2.