PTP Inhibitor V, PHPS1 (CAS 314291-83-3)

5.0(1)

备用名: PhenylHydrazonoPyrazolone Sulfonate 1

应用； PTP Inhibitor V, PHPS1 is a cell-permeable phosphotyrosine mimetic that acts as an active-site targeting inhibitor of Shp-2

CAS号码: 314291-83-3

纯度: ≥95%

分子量: 465.45

分子式: C₂₁H₁₅N₅O₆S

仅供科研使用。不可用于诊断或治疗。

* 参考分析证明大量特定数据 (包括水含量).

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PTP Inhibitor V, PHPS1 is a cell-permeable phosphotyrosine mimetic that acts as a reversible, active-site targeting, substrate-competitive inhibitor of Shp-2 (IC₅₀ and K_i = 2.1 and 0.73 µM, respectively). PHPS1 inhibits ECPTP, PTP1B, Shp1, mycobacterium MptpA only at higher concentrations (IC₅₀ = 5.4, 19, 30, and 39 µM, respectively) and exhibits little activity against PTPH1, STEP, PTPN7, PTPRK, GLEPP1, or LAR2 even at concentrations as high as 50 µM. PTP Inhibitor V, PHPS1 has been shown to inhibit Shp-2-dependent cellular signaling and tumor cell colonies formation.

参考文献

1. Hellmuth, K., et al. 2008. Proc. Natl. Acad. Sci. U.S.A. 105:7275-7280. PMID: 18480264

用法 :

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

物理状态 :

Solid

溶解度 :

Soluble in DMSO (10 mg/ml).

保存 :

Store at 4° C

IC50 :

Shp-2: IC₅₀ = 2.1 µM; EC₅₀PTP: IC₅₀ = 5.4 µM; PTP1B: IC₅₀ = 19 µM; Shp1: IC₅₀ = 30 µM; mycobacterium MptpA: IC₅₀ = 39 µM

Ki 数据 :

Shp-2: K_i= 0.73 µM

仅供科研使用。不可用于诊断或治疗。

PubChem CID :

71433536

SMILES :

[S](O)(=O)(=O)CC4=CC=C(NN=C1C(=NN(C1=O)C2=CC=CC=C2)C3=CC=C(C=C3)C[N+]([O-])=O)C=C4

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