PTP IA-2 Antibody (98/4H6): sc-130570
- PTP IA-2 Antibody (98/4H6) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against the cytoplasmic domain corresponding to amino acids 602-979 of PTP IA-2 of human origin
- recommended for detection of amino acids 618-628 of PTP IA-2 of mouse, rat and human origin by WB, IP, IF and IHC(P)
- m-IgG1 BP-HRP is the preferred secondary detection reagent for PTP IA-2 Antibody (98/4H6) for WB and IHC(P) applications. This reagent is now offered in a bundle with PTP IA-2 Antibody (98/4H6) (see ordering information below).
PTP IA-2 Antibody (98/4H6) is a mouse monoclonal IgG1 antibody that detects PTP IA-2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. PTP IA-2, also known as PTPRN, IA2, ICA512, or RPTPN, is a receptor-type protein tyrosine phosphatase that plays a crucial role in neuroendocrine function. PTP IA-2 is primarily localized to secretory granules within neuroendocrine cells, including pancreatic islet cells, where PTP IA-2 is involved in the regulation of secretory granule exocytosis. The proper functioning of PTP IA-2 is vital for the secretion of hormones such as insulin, and dysregulation can lead to significant metabolic disorders, including insulin-dependent diabetes mellitus (IDDM). Notably, PTP IA-2 serves as an autoantigen, and the presence of autoantibodies against PTP IA-2 is frequently utilized as a diagnostic marker for diabetes. Anti-PTP IA-2 antibody (98/4H6) is an essential tool for researchers investigating the molecular mechanisms underlying neuroendocrine signaling and diabetes pathogenesis.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PTP IA-2 Antibody (98/4H6) | sc-130570 | 200 µg/ml | $322.00 | |||
PTP IA-2 Antibody (98/4H6): m-IgG1 BP-HRP Bundle | sc-542637 | 200 µg Ab; 20 µg BP | $361.00 |