GRK 7 Antibody (C-2): sc-398371

GRK 7 Antibody (C-2) is a mouse monoclonal IgM antibody that detects GRK 7 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-GRK 7 antibody (C-2) is available as a non-conjugated format. GRK 7 plays a crucial role in regulating G protein-coupled receptor (GPCR) signaling, which is essential for various physiological processes, including vision, neurotransmission, and hormone response. Located primarily in the cytoplasm, GRK 7 is recruited to the membrane upon activation of target receptors, where GRK 7 phosphorylates them, leading to receptor desensitization and internalization. This process is vital for maintaining cellular responsiveness to external signals, as GRK 7 prevents overstimulation and allows for the fine-tuning of signaling pathways. GRK 7′s ability to modulate receptor activity underscores its importance in pharmacology and therapeutic interventions, particularly in conditions where GPCR signaling is dysregulated.

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GRK 7 Antibody (C-2) References:

1. Characterization of human GRK7 as a potential cone opsin kinase.  |  Chen, CK., et al. 2001. Mol Vis. 7: 305-13. PMID: 11754336
2. The beta-adrenergic receptors.  |  Wallukat, G. 2002. Herz. 27: 683-90. PMID: 12439640
3. Differential functional expression of human myocardial G protein receptor kinases in left ventricular cardiac diseases.  |  Dzimiri, N., et al. 2004. Eur J Pharmacol. 489: 167-77. PMID: 15087239
4. Highly effective phosphorylation by G protein-coupled receptor kinase 7 of light-activated visual pigment in cones.  |  Tachibanaki, S., et al. 2005. Proc Natl Acad Sci U S A. 102: 9329-34. PMID: 15958532
5. Temporal blastemal cell gene expression analysis in the kidney reveals new Wnt and related signaling pathway genes to be essential for Wilms' tumor onset.  |  Maschietto, M., et al. 2011. Cell Death Dis. 2: e224. PMID: 22048167
6. A tale of two kinases in rods and cones.  |  Osawa, S. and Weiss, ER. 2012. Adv Exp Med Biol. 723: 821-7. PMID: 22183412
7. The origin and evolution of G protein-coupled receptor kinases.  |  Mushegian, A., et al. 2012. PLoS One. 7: e33806. PMID: 22442725
8. A degenerative retinal process in HIV-associated non-infectious retinopathy.  |  Kozak, I., et al. 2013. PLoS One. 8: e74712. PMID: 24069333
9. The Tumor Profiler Study: integrated, multi-omic, functional tumor profiling for clinical decision support.  |  Irmisch, A., et al. 2021. Cancer Cell. 39: 288-293. PMID: 33482122
10. Canonical and Non-Canonical Roles of GRK2 in Lymphocytes.  |  Cheng, J., et al. 2021. Cells. 10: PMID: 33546162
11. Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells.  |  Sun, Y., et al. 2021. Cell Death Dis. 12: 1028. PMID: 34716292
12. An OX-Tra'Ordinary Tale: The Role of OX40 and OX40L in Atopic Dermatitis.  |  Sadrolashrafi, K., et al. 2024. Cells. 13: PMID: 38607026

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GRK 7 Antibody (C-2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-GRK 7 Antibody (C-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GRK 7 Antibody (C-2) Specifications

Alternate Product Name: GRK7

Product Clone Name: C-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 472-501

Epitope Target: GRK 7

Epitope Species: human

Product Reactivity/Detection: GRK 7

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for GRK 7 Antibody (C-2): P: Blocking Peptide