DEK Antibody (2): sc-136222

DEK Antibody (2) is a mouse monoclonal IgG1 kappa light chain antibody that detects DEK in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF) applications. Anti-DEK antibody (2) is available in a non-conjugated form, allowing for versatile experimental setups. DEK is a crucial mammalian nuclear phosphoprotein involved in various cellular processes, including transcriptional regulation, mRNA processing, and chromatin remodeling, which are essential for maintaining cellular homeostasis and gene expression. DEK plays a significant role in the structural organization of chromatin, influencing DNA topology and accessibility, which is vital for proper gene regulation and cellular response to environmental signals. DEK is abundant in the nucleus and interacts with several other proteins, including transcription factors and chromatin remodelers, thereby modulating their activity and stability. DEK has been associated with various clinical conditions, including autoimmune diseases and cancers, highlighting its importance in both health and disease. The human DEK gene is located on chromosome 6p22.3, and DEK′s involvement in pathologies such as acute myelogenous leukemia and juvenile rheumatoid arthritis underscores its relevance in clinical research and therapeutic development.

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DEK Antibody (2) References:

1. The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes.  |  McGarvey, T., et al. 2000. J Cell Biol. 150: 309-20. PMID: 10908574
2. Subcellular localization of the human proto-oncogene protein DEK.  |  Kappes, F., et al. 2001. J Biol Chem. 276: 26317-23. PMID: 11333257
3. The ubiquitous chromatin protein DEK alters the structure of DNA by introducing positive supercoils.  |  Waldmann, T., et al. 2002. J Biol Chem. 277: 24988-94. PMID: 11997399
4. YY1 and NF-Y binding sites regulate the transcriptional activity of the dek and dek-can promoter.  |  Sitwala, KV., et al. 2002. Oncogene. 21: 8862-70. PMID: 12483538
5. Control of tumorigenesis and chemoresistance by the DEK oncogene.  |  Riveiro-Falkenbach, E. and Soengas, MS. 2010. Clin Cancer Res. 16: 2932-8. PMID: 20501624
6. The DEK oncoprotein and its emerging roles in gene regulation.  |  Sandén, C. and Gullberg, U. 2015. Leukemia. 29: 1632-6. PMID: 25765544
7. A role for intracellular and extracellular DEK in regulating hematopoiesis.  |  Capitano, ML. and Broxmeyer, HE. 2017. Curr Opin Hematol. 24: 300-306. PMID: 28306668
8. The Complexity of DEK Signaling in Cancer Progression.  |  Teng, Y., et al. 2018. Curr Cancer Drug Targets. 18: 256-265. PMID: 28530531
9. Role of the DEK oncogene in the development of squamous cell carcinoma.  |  Ishida, K., et al. 2020. Int J Clin Oncol. 25: 1563-1569. PMID: 32656741
10. Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis.  |  Chen, Z., et al. 2021. J Exp Med. 218: PMID: 33755722
11. DEK deficiency suppresses mitophagy to protect against house dust mite-induced asthma.  |  Bai, Q., et al. 2023. Front Immunol. 14: 1289774. PMID: 38274803
12. DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer.  |  Fu, GK., et al. 1997. Proc Natl Acad Sci U S A. 94: 1811-5. PMID: 9050861

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-DEK Antibody (2) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-DEK Antibody (2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

DEK Antibody (2) Specifications

Alternate Product Name: DEK

Product Clone Name: 2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 19-169

Epitope Target: DEK

Epitope Species: human

Product Reactivity/Detection: DEK

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for DEK Antibody (2): N/A