Date published: 2026-4-21

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DEK Inhibitors

DEK inhibitors encompass a range of compounds targeting signaling pathways and cellular processes linked to the function of the DEK protein. These inhibitors modulate key molecular pathways such as histone acetylation, DNA methylation, and various signaling cascades crucial for chromatin remodeling and transcription regulation, where DEK is actively involved. The mechanism of action for these inhibitors involves disrupting the upstream or downstream signaling pathways and altering chromatin states that influence DEK's expression, activity, or downstream effects. Histone deacetylase inhibitors like Trichostatin A, Vorinostat, and SAHA change the chromatin structure and gene expression patterns, potentially disrupting DEK's role in these processes. Similarly, inhibitors targeting PI3K/Akt/mTOR and MAPK/ERK pathways, such as LY294002, PD98059, and Rapamycin, can affect DEK's regulatory role in cell signaling and transcription. DNA methyltransferase and histone methyltransferase inhibitors like 5-Azacytidine and BIX 01294 modify the epigenetic landscape, which can have a knock-on effect on DEK-mediated cellular processes.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$152.00
$479.00
$632.00
$1223.00
$2132.00
33
(3)

Histone deacetylase inhibitor, can alter chromatin structure and gene expression, potentially disrupting DEK's regulatory mechanisms.

Suberoylanilide Hydroxamic Acid

149647-78-9sc-220139
sc-220139A
100 mg
500 mg
$133.00
$275.00
37
(2)

Another histone deacetylase inhibitor, can affect chromatin remodeling and transcription, influencing DEK's role in these processes.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$123.00
$400.00
148
(1)

PI3K inhibitor, can disrupt downstream signaling pathways that modulate DEK activity and localization.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$40.00
$92.00
212
(2)

MEK inhibitor, alters the MAPK/ERK pathway, which can affect DEK-related cellular responses.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

mTOR inhibitor, impacts protein synthesis and degradation pathways, indirectly influencing DEK levels or function.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$64.00
$246.00
136
(2)

MEK1/2 inhibitor, disrupts signaling pathways that may be involved in DEK-mediated processes.

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

DNA methyltransferase inhibitor, can affect DNA methylation patterns, thereby influencing DEK's role in chromatin architecture.

RGFP966

1357389-11-7sc-507300
5 mg
$115.00
(0)

Histone deacetylase 3 inhibitor, specifically impacts gene expression and chromatin structure, potentially affecting DEK's function.

Histone Lysine Methyltransferase Inhibitor Inhibitor

935693-62-2 (free base)sc-202651
5 mg
$151.00
4
(1)

G9a histone methyltransferase inhibitor, potentially affecting chromatin states and DEK expression.

MS-275

209783-80-2sc-279455
sc-279455A
sc-279455B
1 mg
5 mg
25 mg
$24.00
$90.00
$212.00
24
(2)

Another histone deacetylase inhibitor, affects gene expression and chromatin dynamics, potentially impacting DEK.