CD67 Antibody (GM2H6): sc-101383
- CD67 Antibody (GM2H6) is a mouse monoclonal IgG1 κ CD67 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against CD67 of human origin
- CD67 Antibody (GM2H6) is recommended for detection of CD67 of human origin by WB, IP, FCM and ELISA
- Anti-CD67 Antibody (GM2H6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CD67 Antibody (GM2H6) for WB applications. These reagents are now offered in bundles with CD67 Antibody (GM2H6) (see ordering information below).
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CD67 Antibody (GM2H6) is a mouse monoclonal IgG1 kappa light chain antibody that detects CD67 protein of human origin by western blotting (WB), immunoprecipitation (IP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). CD67 (GM2H6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CD67 protein, also known as carcinoembryonic antigen-related cell adhesion molecule 8, is encoded by the CEACAM8 gene and is primarily expressed in neutrophils and eosinophils, playing a crucial role in immune response. CD67 is localized in the secondary granules of neutrophils, where CD67 is essential for mediating cell adhesion and facilitating interactions between immune cells. This localization allows for rapid mobilization and surface expression of CD67 upon granulocyte activation, enhancing immune response during inflammation. CD67 protein′s ability to interact with other adhesion molecules, such as CD66c, underscores CD67′s importance in the late stages of granulocyte differentiation and function. CD67 is also expressed in leukocytes from chronic myeloid leukemia patients and is found in various tissues, including bone marrow, spleen, thymus, and lungs, highlighting CD67′s relevance in both normal and pathological conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD67 Antibody (GM2H6) References:
- Synovial PMN show a coordinated up-regulation of CD66 molecules. | Hönig, M., et al. 1999. J Leukoc Biol. 66: 429-36. PMID: 10496313
- Augmented expression and release of nonspecific cross-reacting antigens (NCAs), members of the CEA family, by human neutrophils during cell activation. | Kuroki, M., et al. 1992. J Leukoc Biol. 52: 551-7. PMID: 1431566
- Analysis of function-associated receptor molecules on peripheral blood and synovial fluid granulocytes from patients with rheumatoid and reactive arthritis. | Felzmann, T., et al. 1991. J Clin Immunol. 11: 205-12. PMID: 1918267
- Carcinoembryonic antigen gene family: molecular biology and clinical perspectives. | Thompson, JA., et al. 1991. J Clin Lab Anal. 5: 344-66. PMID: 1941355
- Characterization of a cDNA clone encoding a new species of the nonspecific cross-reacting antigen (NCA), a member of the CEA gene family. | Arakawa, F., et al. 1990. Biochem Biophys Res Commun. 166: 1063-71. PMID: 2306228
- Monoclonal antibodies identify a CEA crossreacting antigen of 95 kD (NCA-95) distinct in antigenicity and tissue distribution from the previously described NCA of 55 kD. | Buchegger, F., et al. 1984. Int J Cancer. 33: 643-9. PMID: 6724739
- Transcriptional control of the human biliary glycoprotein gene, a CEA gene family member down-regulated in colorectal carcinomas. | Hauck, W., et al. 1994. Eur J Biochem. 223: 529-41. PMID: 8055923
- Preparation and characterization of two human carcinoembryonic antigen family proteins of neutrophils, CD66b and c, in silkworm larvae. | Yamanaka, T., et al. 1996. Protein Expr Purif. 7: 438-46. PMID: 8776764
- Mice transgenic for the human CGM6 gene express its product, the granulocyte marker CD66b, exclusively in granulocytes. | Eades-Perner, AM., et al. 1998. Blood. 91: 663-72. PMID: 9427723
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD67 Antibody (GM2H6) | sc-101383 | 200 µg/ml | $322.00 | |||
CD67 Antibody (GM2H6): m-IgG Fc BP-HRP Bundle | sc-528716 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD67 Antibody (GM2H6): m-IgGκ BP-HRP Bundle | sc-521187 | 200 µg Ab, 40 µg BP | $361.00 | |||
CD67 Antibody (GM2H6): m-IgG1 BP-HRP Bundle | sc-543086 | 200 µg Ab; 20 µg BP | $361.00 | |||
CD67 Antibody (GM2H6) AC | sc-101383 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CD67 Antibody (GM2H6) HRP | sc-101383 HRP | 200 µg/ml | $322.00 | |||
CD67 Antibody (GM2H6) FITC | sc-101383 FITC | 200 µg/ml | $336.00 | |||
CD67 Antibody (GM2H6) PE | sc-101383 PE | 200 µg/ml | $349.00 | |||
CD67 Antibody (GM2H6) Alexa Fluor® 488 | sc-101383 AF488 | 200 µg/ml | $364.00 | |||
CD67 Antibody (GM2H6) Alexa Fluor® 546 | sc-101383 AF546 | 200 µg/ml | $364.00 | |||
CD67 Antibody (GM2H6) Alexa Fluor® 594 | sc-101383 AF594 | 200 µg/ml | $364.00 | |||
CD67 Antibody (GM2H6) Alexa Fluor® 647 | sc-101383 AF647 | 200 µg/ml | $364.00 | |||
CD67 Antibody (GM2H6) Alexa Fluor® 680 | sc-101383 AF680 | 200 µg/ml | $364.00 | |||
CD67 Antibody (GM2H6) Alexa Fluor® 790 | sc-101383 AF790 | 200 µg/ml | $364.00 |