TSG-6 Antibody (A68.13.13): sc-65888

TSG-6 Antibody (A68.13.13) is a rat monoclonal IgG2a antibody designed to recognize TSG-6, also known as TNF-stimulated gene 6 or tumor necrosis factor-inducible gene 6 protein, across mouse, rat, and human species using western blotting (WB) and immunoprecipitation (IP) applications. TSG-6 is an extracellular glycoprotein characterized by its complex structure, which includes a Link module domain critical for binding hyaluronan and two CUB domains that facilitate interactions with other proteins, making TSG-6 a key player in extracellular matrix organization and inflammatory responses. The structural integrity of TSG-6 is essential for its function in modulating inflammation and tissue remodeling, particularly through TSG-6′s ability to form stable complexes with inter-α-inhibitor (IαI), thereby regulating the protease network and suppressing excessive inflammatory activity. Anti-TSG-6 antibody (A68.13.13) targets an epitope raised against a CTLL-2 cell line expressing a CD44 chimera of human origin. TSG-6 is rapidly upregulated in response to pro-inflammatory cytokines such as TNFα and IL-1, underscoring TSG-6′s importance in immune responses and the pathogenesis of conditions like rheumatoid arthritis. By utilizing TSG-6 monoclonal antibody (A68.13.13), researchers can effectively investigate the structural-functional relationships of TSG-6 in both normal physiological processes and disease states, facilitating a deeper understanding of TSG-6′s role in inflammation and extracellular matrix dynamics. Available for western blotting (WB) and immunoprecipitation (IP), anti-TSG-6 antibody (A68.13.13) is an essential tool for advancing studies in cellular biology, immunology, and related biomedical fields.

The preferred TSG-6 antibody is TSG-6 Antibody (A38.1.20): sc-65886.