MIC2 Antibody (1C3): sc-53898
- MIC2 Antibody (1C3) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against cells from stem T-cell leukemia of human origin
- recommended for detection of MIC2 of human origin by WB, IP, IF and IHC(P)
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MIC2 Antibody (1C3) for WB and IHC(P) applications. These reagents are now offered in bundles with MIC2 Antibody (1C3) (see ordering information below).
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MIC2 Antibody (1C3) is a mouse monoclonal IgG1 antibody that detects MIC2 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. MIC2, also known as CD99, is a critical T cell surface protein that plays a significant role in lymphocyte aggregation, essential for effective immune responses. MIC2 exists in two forms due to alternative splicing: the major form promotes cellular adhesion, while the truncated form inhibits this process. This balance is crucial as MIC2 regulates the interaction between lymphocytes and other cells through the LFA-1/ICAM-1 pathway, influencing immune cell migration and function. Notably, overexpression of the truncated form of MIC2 can lead to downregulation of LFA-1, resulting in cells that exhibit a Hodgkin′s and Reed-Sternberg (H-RS) phenotype, highlighting MIC2′s importance in maintaining normal cell function and morphology. Anti-MIC2 antibody (1C3) serves as an invaluable tool for researchers studying lymphocyte behavior and the underlying mechanisms of immune regulation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MIC2 Antibody (1C3) References:
- Inhibin and CD99 (MIC2) expression in uterine stromal neoplasms with sex-cord-like elements. | Baker, RJ., et al. 1999. Hum Pathol. 30: 671-9. PMID: 10374776
- A study of the coregulation and tissue specificity of XG and MIC2 gene expression in eukaryotic cells. | Fouchet, C., et al. 2000. Blood. 95: 1819-26. PMID: 10688843
- Alternative EWS-FLI1 fusion gene and MIC2 expression in peripheral and central primitive neuroectodermal tumors. | Ishii, N., et al. 2001. Neuropathology. 21: 40-4. PMID: 11304041
- Modulation of CD99/MIC2 expression of human AHTO-7 osteoblasts by carcinoma cell line-conditioned media. | Hamilton, D., et al. 2001. Anticancer Res. 21: 3909-13. PMID: 11911268
- MIC2 is a specific marker for Ewing's sarcoma and peripheral primitive neuroectodermal tumors. Evidence for a common histogenesis of Ewing's sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration. | Ambros, IM., et al. 1991. Cancer. 67: 1886-93. PMID: 1848471
- MIC2: a human pseudoautosomal gene. | Goodfellow, PN., et al. 1988. Philos Trans R Soc Lond B Biol Sci. 322: 145-54. PMID: 2907798
- MIC2 analysis of small cell carcinoma. | Lumadue, JA., et al. 1994. Am J Clin Pathol. 102: 692-4. PMID: 7524308
- Androgen regulation of the human pseudoautosomal gene MIC2, a potential marker for prostate cancer. | Shen, J., et al. 1998. Mol Carcinog. 23: 13-9. PMID: 9766433
- Fine-needle aspiration biopsy of metastatic Ewing's sarcoma with MIC2 (CD99) immunocytochemistry. | Collins, BT., et al. 1998. Diagn Cytopathol. 19: 382-4. PMID: 9812236
- Generation of cells with Hodgkin's and Reed-Sternberg phenotype through downregulation of CD99 (Mic2). | Kim, SH., et al. 1998. Blood. 92: 4287-95. PMID: 9834235
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MIC2 Antibody (1C3) | sc-53898 | 200 µg/ml | $322.00 | |||
MIC2 Antibody (1C3): m-IgG Fc BP-HRP Bundle | sc-537013 | 200 µg Ab; 10 µg BP | $361.00 | |||
MIC2 Antibody (1C3): m-IgGκ BP-HRP Bundle | sc-534193 | 200 µg Ab; 40 µg BP | $361.00 | |||
MIC2 Antibody (1C3): m-IgG1 BP-HRP Bundle | sc-544956 | 200 µg Ab; 20 µg BP | $361.00 |