LKB1 Antibody (H-3): sc-374324
- LKB1 Antibody (H-3) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-75 mapping at the N-terminus of LKB1 of human origin
- recommended for detection of LKB1 of human origin by WB, IP, IF and ELISA
- See LKB1 (Ley 37D/G6): sc-32245 for LKB1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for LKB1 Antibody (H-3) for WB applications. This reagent is now offered in a bundle with LKB1 Antibody (H-3) (see ordering information below).
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LKB1 Antibody (H-3) is a mouse monoclonal IgG2a kappa light chain antibody specifically engineered to recognize LKB1, also known as STK11 or serine/threonine kinase 11, in human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-LKB1 antibody (H-3) targets an epitope within the first 75 amino acids at the N-terminus of human LKB1, ensuring effective detection in various experimental settings. LKB1 is a 433 amino acid serine/threonine kinase that plays a pivotal role in regulating cellular energy homeostasis, cell polarity, and metabolism by activating AMP-activated protein kinase (AMPK) and other related kinases. The structure of LKB1 includes a conserved kinase domain essential for enzymatic activity, as well as regulatory regions that facilitate interaction with other proteins and substrates. Post-translational modifications of LKB1, such as phosphorylation and ubiquitination, are critical for modulating activity, stability, and localization within the cell, thereby influencing ability to act as a tumor suppressor. Mutations and alterations in LKB1 are strongly associated with Peutz-Jeghers Syndrome (PJS), a hereditary disorder characterized by benign polyps in the gastrointestinal tract, pigmented spots on the lips, and an increased risk of various cancers. Understanding these modifications and structural integrity of LKB1 is essential for elucidating role in cancer biology and metabolic regulation. LKB1 monoclonal antibody (H-3) is an invaluable tool for researchers investigating molecular mechanisms underlying tumor suppression, cellular metabolism, and signaling pathways. Available in a non-conjugated form, LKB1 (H-3) antibody provides reliable and consistent performance for studies focused on functional analysis of LKB1. By facilitating precise detection and analysis of post-translationally modified forms of LKB1, anti-LKB1 antibody (H-3) supports advancements in understanding disease mechanisms and developing targeted therapies.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LKB1 Antibody (H-3) | sc-374324 | 200 µg/ml | $322.00 | |||
LKB1 Antibody (H-3): m-IgG Fc BP-HRP Bundle | sc-540437 | 200 µg Ab; 10 µg BP | $361.00 |