GlyR α1 Antibody (2E7): sc-293498

GlyR α1 Antibody (2E7) is a mouse monoclonal IgG2a kappa light chain antibody that detects GlyR alpha 1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-GlyR alpha 1 antibody (2E7) is available as a non-conjugated format. GlyR alpha 1 protein plays a crucial role in the central nervous system by mediating inhibitory neurotransmission through glycine receptors, which are vital for voluntary motor control and reflex responses. Glycine binds to these receptors located in postsynaptic neuronal membranes, facilitating chloride ion flow and contributing to neuron hyperpolarization. This process maintains the balance of excitatory and inhibitory signals in the brain, critical for proper motor function and coordination. The pentameric structure of GlyR consists of various subunits, including α1 through α4 and β, which assemble to form a chloride-selective ion channel. The composition shifts from α2 in the fetal central nervous system to α1 and β in adults, highlighting the dynamic nature of glycine receptor function throughout development. The interaction of GlyR with intracellular calcium ions suggests a complex regulatory mechanism that enhances glycinergic synaptic transmission, further underscoring GlyR alpha 1′s importance in neurophysiological processes. The genes encoding human GlyR subunits are located on specific chromosomes, with GlyR α1 mapping to chromosome 5q32, providing insights into glycine receptor function and implications in neurological disorders.

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GlyR α1 Antibody (2E7) References:

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