GlyR Activators
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D-Alanine | 338-69-2 | sc-203558 | 5 g | $36.00 | ||
D-Alanine is a non-proteinogenic amino acid that plays a crucial role in neurotransmission as a selective agonist for glycine receptors (GlyRs). Its unique stereochemistry allows for specific binding interactions, influencing receptor conformational changes and ion channel activity. This selectivity affects synaptic transmission dynamics, modulating inhibitory signaling pathways. Additionally, D-Alanine's presence can alter the kinetics of receptor activation, impacting neuronal excitability and overall synaptic plasticity. | ||||||
Taurine | 107-35-7 | sc-202354 sc-202354A | 25 g 500 g | $48.00 $102.00 | 1 | |
Taurine is a sulfonic acid that interacts with glycine receptors (GlyRs) as a modulator, influencing their activity through distinct allosteric mechanisms. Its unique structure allows for specific binding, which can enhance or inhibit receptor function, thereby affecting chloride ion flow. This modulation can lead to alterations in synaptic strength and neuronal signaling pathways, contributing to the fine-tuning of excitatory and inhibitory balance in neural circuits. | ||||||
Hypotaurine | 300-84-5 | sc-204005 | 100 mg | $53.00 | 1 | |
Hypotaurine, a derivative of taurine, exhibits intriguing interactions with glycine receptors (GlyRs) by acting as a competitive antagonist. Its structural nuances facilitate selective binding, which can disrupt chloride ion permeability and alter receptor conformations. This modulation impacts synaptic transmission dynamics, influencing the excitatory-inhibitory equilibrium within neural networks. Additionally, hypotaurine's unique electron-donating properties may affect redox states in cellular environments. | ||||||
Thiocolchicoside | 602-41-5 | sc-202839 sc-202839A | 1 mg 5 mg | $30.00 $120.00 | ||
Thiocolchicoside interacts with glycine receptors (GlyRs) through a unique mechanism, functioning as a potent modulator. Its specific molecular structure allows for high-affinity binding, influencing receptor gating and ion flow. This interaction can lead to altered synaptic signaling pathways, affecting neurotransmitter release and receptor desensitization. Furthermore, its distinct stereochemistry may enhance selectivity for GlyRs over other ion channels, providing insights into receptor pharmacodynamics. | ||||||
β-Alanine | 107-95-9 | sc-364682 sc-364682A | 25 g 500 g | $32.00 $98.00 | ||
β-Alanine serves as a significant modulator of glycine receptors (GlyRs), exhibiting unique binding characteristics that enhance receptor activation. Its structural conformation facilitates specific interactions with the receptor's binding site, promoting ion channel opening and influencing chloride ion permeability. This modulation can lead to alterations in synaptic transmission dynamics, impacting overall neuronal excitability. Additionally, β-Alanine's kinetic profile suggests a rapid onset of action, contributing to its role in fine-tuning synaptic responses. | ||||||