G9a抗体(C-9): sc-515726

G9a Antibody (C-9) is a high quality monoclonal G9a antibody (also designated EHMT2 antibody, Euchromatic Histone Lysine Methyltransferase 2 antibody, KMT1C antibody, Euchromatic Histone-Lysine N-Methyltransferase 2 antibody, Histone-Lysine N-Methyltransferase EHMT2 antibody, Histone H3-K9 Methyltransferase 3 antibody, HLA-B Associated Transcript 8 antibody, Lysine N-Methyltransferase 1C antibody, H3-K9-HMTase 3 antibody, C6orf30 antibody, BAT8 antibody, NG36 antibody, Chromosome 6 Open Reading Frame 30 antibody, or G9A Histone Methyltransferase antibody) suitable for the detection of the G9a protein of mouse, rat and human origin. G9a Antibody (C-9) is available as both the non-conjugated anti-G9a antibody form, as well as multiple conjugated forms of anti-G9a antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor^® conjugates. Distinct modifications of histone tails, such as acetylation, phosphorlation and methylation, regulate nuclear processes, such as control of transcription and mitotic chromosome condensation. Histone methyltransferases (HMTases) are among the different groups of enzymes known to catalyze the covalent modification. G9a, a SET domain-containing protein, is a novel mammalian lysine-preferring HMTase. G9a, also known as BAT8, NG36 or HMTase (for mammalian histone methyltransferase), has strong HMTase activity towards histone H3 lysine 9 methylation in vitro (2-4). G9a plays a dominant role in euchromatic histone H3 lysine 9 methylation, is essential for early embryogenesis and is involved in the transcriptional repression of developmental genes. Like SUV39H, G9a transfers methyl groups to the lysine residues of histone H3, but with a 10-20-fold higher activity than SUV39H1. G9a also adds methyl groups to lysine 27 as well as lysine 9 in histone H3. G9a localizes in the nucleus, indicating that it may contribute to the organization of the higher order chromatin structure of non-centromeric loci. The human G9a gene maps to chromosome 6p21.3 (3,5,6).

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