G9a Activators
G9a activators refer to a class of chemical compounds that are specifically designed to modulate the activity of the G9a protein, an important epigenetic regulator in the field of molecular biology. G9a, also known as EHMT2 (euchromatic histone-lysine N-methyltransferase 2), is an enzyme responsible for adding methyl groups to histone proteins. This methylation process plays a pivotal role in gene regulation by altering the chromatin structure, making it either more permissive or repressive for gene expression. G9a primarily catalyzes the addition of methyl groups to lysine 9 of histone H3 (H3K9), resulting in a compacted chromatin structure and gene silencing. G9a activators, as their name implies, are compounds designed to enhance the enzymatic activity of G9a, potentially leading to increased methylation of H3K9 and, consequently, affecting gene expression patterns.
Chemically, G9a activators can be diverse, encompassing a range of small molecules, peptides, or other agents that interact with G9a or its cofactors to augment its catalytic function. By doing so, they may have the ability to impact various cellular processes and pathways influenced by G9a-mediated epigenetic modifications. Researchers and scientists are interested in studying these activators to better understand the fundamental mechanisms of epigenetic regulation and the consequences of altering G9a activity in a controlled laboratory setting. Additionally, G9a activators can serve as valuable tools in elucidating the intricate interplay between epigenetic modifications and cellular functions, contributing to our broader understanding of gene regulation and its implications in various biological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a cytidine analog that incorporates into DNA and RNA, leading to hypomethylation of DNA. This may indirectly increase G9a expression by altering the methylation status of its promoter region. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenolic compound found in grapes. It influences various signaling pathways, potentially upregulating G9a to mediate cellular responses to stress and maintain genomic stability. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor, leading to hyperacetylation of histones and changes in chromatin structure. These alterations could potentially upregulate G9a expression as part of a cellular compensatory mechanism. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3 regulates gene expression through its receptor, VDR. It may induce G9a expression as part of a broader regulatory network controlling cell growth and differentiation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a derivative of vitamin A, plays a crucial role in cell differentiation and growth. It may influence G9a expression as part of its extensive network of gene regulation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a short-chain fatty acid and histone deacetylase inhibitor. It may alter chromatin structure and gene expression, potentially upregulating G9a as part of cellular adaptation to its effects. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
This is a major catechin in green tea, known for its antioxidant properties. It may influence gene expression and chromatin state, potentially modulating G9a levels as part of its cellular effects. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels. This signaling cascade can lead to changes in gene expression, potentially including the upregulation of G9a. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride affects glycogen synthase kinase-3 (GSK-3) activity and has various impacts on gene expression. It could potentially upregulate G9a as part of its influence on cellular pathways. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Metformin activates AMP-activated protein kinase (AMPK), influencing various cellular processes. It may modulate G9a expression as part of its broader effects on cell metabolism and growth. | ||||||