CD3 Antibody (PS1): sc-59013
- CD3 Antibody (PS1) is a mouse monoclonal IgG2a, cited in 9 publications, provided at 250 µl supernatant
- raised against a prokaryotic fusion protein corresponding to the epsilon chain of CD3 of human origin
- recommended for detection of CD3 of mouse, rat and human origin by WB, IP, IF and IHC(P); also reactive with additional species, including canine
- See CD3 (PC3/188A): sc-20047 for CD3 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD3 Antibody (PS1). This work is in progress.
CD3 Antibody (PS1) is a mouse monoclonal IgG2a antibody specifically designed to detect CD3 protein across multiple species, including mouse, rat, human, and canine, utilizing applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). CD3, also known as the T cell co-receptor complex or the TCR-CD3 complex, is an essential component located on the surface of T lymphocytes, where CD3 plays a pivotal role in T cell receptor (TCR) signaling and activation. This strategic localization on the cell membrane is crucial for initiating immune responses, enabling T cells to recognize and respond effectively to pathogens, and maintaining immune homeostasis. Structurally, the CD3 complex comprises five invariant polypeptide chains, gamma, epsilon, delta, zeta, and eta, that form three distinct dimers, facilitating the transmission of extracellular antigen recognition into intracellular activation signals. CD3 interacts with key signaling proteins such as ZAP-70 and Lck, which are vital for propagating downstream signaling cascades that lead to T cell proliferation and differentiation. CD3 (PS1) monoclonal antibody is an indispensable tool for researchers studying T cell function, immune signaling pathways, and related therapeutic developments.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD3 Antibody (PS1) | sc-59013 | 250 µl supernatant | $322.00 |