Aldehyde dehydrogenase /2/ALDH1A1/2/3/ALDH2抗体(H-8): sc-166362

ALDH1/2 Antibody (H-8) is a high quality monoclonal ALDH1/2 antibody (also designated ALDH1A1/A2/A3/2 antibody) suitable for the detection of the ALDH1/2 protein of mouse, rat and human origin. ALDH1/2 Antibody (H-8) is available as both the non-conjugated anti-ALDH1/2 antibody form, as well as multiple conjugated forms of anti-ALDH1/2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor^® conjugates. Aldehyde dehydrogenases (ALDHs) mediate NADP+-dependent oxidation of aldehydes into acids during the detoxification of alcohol-derived acetaldehyde; metabolism of corticosteroids, biogenic amines and neurotransmitters; and lipid peroxidation. ALDH1A1, also designated retinal dehydrogenase 1 (RalDH1 or RALDH1); aldehyde dehydrogenase family 1 member A1; aldehyde dehydrogenase cytosolic; ALDHII; ALDH-E1 or ALDH E1, is a retinal dehydrogenase that participates in the biosynthesis of retinoic acid (RA). The major liver isoform ALDH1 localizes to cytosolic space, while ALDH2 localizzes to the mitochondria. The ALDH1A2 (RALDH2, RALDH2-T) gene produces three different transcripts and also catalyzes the synthesis of RA from retinaldehyde. ALDH2 is present in most Caucasians, yet is absent in 50% of Asians. The absence of this enzyme has been linked to alcohol intolerance; and thusly, a reduced risk for alcoholism-related liver disease.

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