Aladin Antibody (B-11): sc-374073
- Aladin Antibody (B-11) is a mouse monoclonal IgG1 κ Aladin antibody, cited in 5 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 501-531 near the C-terminus of Aladin of human origin
- Aladin Antibody (B-11) is recommended for detection of Aladin of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including bovine
- Anti-Aladin Antibody (B-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Aladin Antibody (B-11) for WB applications. These reagents are now offered in bundles with Aladin Antibody (B-11) (see ordering information below).
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SEE ALSO...
Aladin Antibody (B-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects Aladin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Aladin (B-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Aladin protein, also known as Adracalin, is a member of the WD repeat-containing protein family, which is involved in diverse cellular processes such as signal transduction, RNA processing, and transcription regulation. Aladin protein plays a crucial role in the development of the peripheral and central nervous systems, with expression being particularly high in the pituitary gland, corpus callosum, cerebellum, adrenal gland, and gastrointestinal structures. Defects in Aladin protein are linked to the autosomal recessive disorder known as achalasia-addisonianism-alacrima (triple A) syndrome, which manifests through symptoms such as achalasia, alacrima, and adrenal insufficiency resistant to adrenocorticotropic hormone. Robust expression of Aladin in neural systems that govern cognitive, motor, and sensory functions underscores the complexity of symptoms experienced by patients with triple A syndrome, making studies of Aladin protein vital for understanding implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Aladin Antibody (B-11) References:
- Mutant WD-repeat protein in triple-A syndrome. | Tullio-Pelet, A., et al. 2000. Nat Genet. 26: 332-5. PMID: 11062474
- Analysis of the AAAS gene in a Japanese patient with triple A syndrome. | Katsumata, N., et al. 2002. Endocr J. 49: 49-53. PMID: 12008750
- Clinical and genetic characterization of families with triple A (Allgrove) syndrome. | Houlden, H., et al. 2002. Brain. 125: 2681-90. PMID: 12429595
- The nuclear pore complex protein ALADIN is mislocalized in triple A syndrome. | Cronshaw, JM. and Matunis, MJ. 2003. Proc Natl Acad Sci U S A. 100: 5823-7. PMID: 12730363
- Identification of the sites of expression of triple A syndrome mRNA in the rat using in situ hybridisation. | Storr, HL., et al. 2005. Neuroscience. 131: 113-23. PMID: 15680696
- The diagnosis of adrenal insufficiency in a patient with Allgrove syndrome and a novel mutation in the ALADIN gene. | Salehi, M., et al. 2005. Metabolism. 54: 200-5. PMID: 15690314
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aladin Antibody (B-11) | sc-374073 | 200 µg/ml | $322.00 | |||
Aladin Antibody (B-11): m-IgG Fc BP-HRP Bundle | sc-529651 | 200 µg Ab; 10 µg BP | $361.00 | |||
Aladin Antibody (B-11): m-IgGκ BP-HRP Bundle | sc-522609 | 200 µg Ab, 40 µg BP | $361.00 | |||
Aladin Antibody (B-11): m-IgG1 BP-HRP Bundle | sc-543623 | 200 µg Ab; 20 µg BP | $361.00 | |||
Aladin Antibody (B-11) AC | sc-374073 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Aladin Antibody (B-11) HRP | sc-374073 HRP | 200 µg/ml | $322.00 | |||
Aladin Antibody (B-11) FITC | sc-374073 FITC | 200 µg/ml | $336.00 | |||
Aladin Antibody (B-11) PE | sc-374073 PE | 200 µg/ml | $349.00 | |||
Aladin Antibody (B-11) Alexa Fluor® 488 | sc-374073 AF488 | 200 µg/ml | $364.00 | |||
Aladin Antibody (B-11) Alexa Fluor® 546 | sc-374073 AF546 | 200 µg/ml | $364.00 | |||
Aladin Antibody (B-11) Alexa Fluor® 594 | sc-374073 AF594 | 200 µg/ml | $364.00 | |||
Aladin Antibody (B-11) Alexa Fluor® 647 | sc-374073 AF647 | 200 µg/ml | $364.00 | |||
Aladin Antibody (B-11) Alexa Fluor® 680 | sc-374073 AF680 | 200 µg/ml | $364.00 | |||
Aladin Antibody (B-11) Alexa Fluor® 790 | sc-374073 AF790 | 200 µg/ml | $364.00 | |||
Aladin (B-11) Neutralizing Peptide | sc-374073 P | 100 µg/0.5 ml | $69.00 |