SLC17A2 inhibitors are a class of chemical compounds that specifically target and inhibit the function of the SLC17A2 protein, a member of the solute carrier family. SLC17A2 is part of the larger SLC17 family, which is known for its role in transporting organic anions, including neurotransmitters and other small molecules, across cellular membranes. The inhibition of SLC17A2 can disrupt the transport processes it mediates, offering researchers a powerful tool to study the protein's function and its broader impact on cellular activities. By selectively inhibiting SLC17A2, scientists can explore how this transporter influences the distribution and concentration of specific anions within cells, and how these changes affect cellular metabolism and signaling.
The use of SLC17A2 inhibitors in research is particularly valuable for dissecting the role of this transporter in various biological systems. By blocking SLC17A2 activity, researchers can observe the resulting alterations in cellular processes, such as changes in ion gradients, neurotransmitter release, and intracellular signaling pathways. These studies help to elucidate the specific substrates transported by SLC17A2 and the physiological contexts in which this transporter is most active. Additionally, SLC17A2 inhibitors can be used to explore the regulatory mechanisms that control the expression and activity of this protein, providing insights into how cells maintain homeostasis in response to environmental and intracellular cues. Through these investigations, SLC17A2 inhibitors contribute to a deeper understanding of membrane transport mechanisms and the complex interplay between transport proteins and cellular function.
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| 製品名 | CAS # | カタログ # | 数量 | 価格 | 引用文献 | レーティング |
|---|---|---|---|---|---|---|
Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | $27.00 $38.00 $98.00 $272.00 | 28 | |
さまざまな陰イオン輸送体を競合的に阻害し、SLC17ファミリーの機能を低下させる可能性がある。 | ||||||
Phloridzin | 60-81-1 | sc-219613 | 2.5 g | $388.00 | ||
ナトリウム依存性輸送体を阻害し、リン酸の競合的取り込みを低下させる可能性がある。 | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $28.00 $37.00 | 18 | |
プロスタグランジン合成に影響を与え、腎輸送の動態を変化させることで、間接的に陰イオン輸送体を阻害する。 | ||||||
Furosemide | 54-31-9 | sc-203961 | 50 mg | $40.00 | ||
ループ利尿薬で、NKCC2を阻害し、リン酸輸送に二次的な影響を及ぼす可能性がある。 | ||||||
Bumetanide (Ro 10-6338) | 28395-03-1 | sc-200727 sc-200727A | 1 g 5 g | $107.00 $224.00 | 9 | |
フロセミドと同様、NKCC2を阻害し、間接的にSLC17Aの活性に影響を及ぼす可能性がある。 | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
イノシトール一リン酸分解酵素に影響を及ぼし、陰イオン輸送の変化につながる可能性があり、SLC17Aの機能を変化させる可能性がある。 | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $32.00 | ||
脂質代謝に影響を及ぼし、膜特性を変化させることで膜輸送体に影響を及ぼす可能性がある。 | ||||||
Hydrochlorothiazide | 58-93-5 | sc-207738 sc-207738A sc-207738B sc-207738C sc-207738D | 5 g 25 g 50 g 100 g 250 g | $54.00 $235.00 $326.00 $551.00 $969.00 | ||
電解質の再吸収に影響を与えるチアジド系利尿薬は、間接的にSLC17A関連輸送に影響を与える可能性がある。 | ||||||
Chlorothiazide | 58-94-6 | sc-202536 sc-202536A sc-202536B | 1 g 5 g 10 g | $38.00 $105.00 $172.00 | ||
ヒドロクロロチアジドと同様に、イオンバランスを変化させることで間接的にSLC17A活性に影響を与える可能性がある。 | ||||||