TSG-6 Antibody (Q75.2.10): sc-65889
- TSG-6 Antibody (Q75.2.10) is a rat monoclonal IgG1, cited in 1 publications, provided at 200 µg/ml
- raised against XJ(3) cell line expressing the CD44/TSG chimera of human origin
- recommended for detection of TSG-6 of mouse, rat and human origin by WB and IP
- See TSG-6 (E-1): sc-377277 for TSG-6 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for TSG-6 Antibody (Q75.2.10). This work is in progress.
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TSG-6 Antibody (Q75.2.10) is a rat monoclonal IgG1 antibody engineered to detect TSG-6 protein, also known as TNF-stimulated gene 6 or tumor necrosis factor-inducible gene 6 protein, across mouse, rat, and human species using western blotting (WB) and immunoprecipitation (IP) techniques. TSG-6 is an extracellular glycoprotein that plays a critical role in modulating inflammation and maintaining extracellular matrix stability, which is essential for processes such as tissue repair and inflammatory diseases like rheumatoid arthritis. Structurally, TSG-6 contains a Link module domain responsible for binding hyaluronan and two CUB domains that facilitate interactions with other proteins, enabling formation of stable complexes with inter-α-inhibitor (IαI) and regulation of the protease network to suppress excessive inflammatory responses. Post-translational modifications, particularly glycosylation, are vital for proper folding, stability, and functional interactions of TSG-6, enhancing modulation of the extracellular environment. Anti-TSG-6 antibody (A68.13.13) targets an epitope raised against a CTLL-2 cell line expressing a CD44 chimera of human origin, allowing for detection in various experimental settings. Expression of TSG-6 is rapidly upregulated in response to pro-inflammatory cytokines such as TNFα and IL-1, highlighting significance in immune responses and tissue remodeling. TSG-6 monoclonal antibody (A68.13.13) enables researchers to effectively investigate structural and functional dynamics of TSG-6 in both normal physiological processes and disease states, providing valuable insights into inflammation and extracellular matrix interactions. Available for western blotting (WB) and immunoprecipitation (IP), anti-TSG-6 antibody (A68.13.13) advances studies in cellular biology, immunology, and related biomedical fields, enabling deeper understanding of mechanisms underlying inflammatory responses and tissue homeostasis.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TSG-6 Antibody (Q75.2.10) | sc-65889 | 200 µg/ml | $322.00 |