Thrombospondin 1 Antibody (TX17.10): sc-65210

Thrombospondin 1 Antibody (TX17.10) is a rat monoclonal IgG2a antibody designed to detect Thrombospondin 1 (TSP-1), also known as cartilage-derived retinoic acid-sensitive protein (CD-RAP) in cartilage-related studies. Anti-Thrombospondin 1 antibody (TX17.10) is raised against mouse Thrombospondin 1, ensuring precise recognition of the target protein. Thrombospondin 1 is a large, multidomain extracellular glycoprotein characterized by its complex structure, which includes multiple thrombospondin type 1 repeats (TSRs). These structural domains facilitate TSP-1′s interactions with a variety of cell surface receptors and extracellular matrix components, making its structure crucial for mediating cell-to-cell and cell-to-matrix signaling. The intricate architecture of TSP-1 allows TSP-1 to play essential roles in processes such as platelet aggregation, cellular adhesion, migration, and the regulation of tissue development and repair. By targeting specific structural domains, Thrombospondin 1 monoclonal antibody (TX17.10) enables researchers to investigate the functional implications of TSP-1′s interactions and structural conformation in various biological contexts. Anti-Thrombospondin 1 antibody (TX17.10) is validated for use in western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM), providing reliable performance in these applications. Thrombospondin 1 antibody (TX17.10) does not cross-react with other thrombospondin family members or unrelated proteins, ensuring accurate and consistent results. Using Thrombospondin 1 antibody (TX17.10), scientists can gain deeper insights into the structural-functional relationships of TSP-1, advancing our understanding of its role in physiological and pathological mechanisms.

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Thrombospondin 1 Antibody (TX17.10) References:

1. Thrombospondin-1 and cutaneous melanoma.  |  Trotter, MJ., et al. 2003. J Cutan Med Surg. 7: 136-41. PMID: 12447621
2. Thrombospondin-1 is a multifaceted player in tumor progression.  |  Huang, T., et al. 2017. Oncotarget. 8: 84546-84558. PMID: 29137447
3. Role of thrombospondin‑1 and thrombospondin‑2 in cardiovascular diseases (Review).  |  Zhang, K., et al. 2020. Int J Mol Med. 45: 1275-1293. PMID: 32323748
4. Thrombospondin-1: A Key Protein That Induces Fibrosis in Diabetic Complications.  |  Xu, L., et al. 2020. J Diabetes Res. 2020: 8043135. PMID: 32626782
5. Thrombospondin 1 and 2 along with PEDF inhibit angiogenesis and promote lymphangiogenesis in intrahepatic cholangiocarcinoma.  |  Carpino, G., et al. 2021. J Hepatol. 75: 1377-1386. PMID: 34329660
6. Thrombospondin-1 in drug activity and tumor response to therapies.  |  Longhi, E., et al. 2024. Semin Cell Dev Biol. 155: 45-51. PMID: 37414720
7. Thrombospondin-1 in vascular development, vascular function, and vascular disease.  |  Liu, B., et al. 2024. Semin Cell Dev Biol. 155: 32-44. PMID: 37507331
8. New insights into the role of thrombospondin-1 in glioblastoma development.  |  Bikfalvi, A., et al. 2024. Semin Cell Dev Biol. 155: 52-57. PMID: 37690904
9. The Contributions of Thrombospondin-1 to Epilepsy Formation.  |  Cheng, Y., et al. 2024. Neurosci Bull. 40: 658-672. PMID: 38528256
10. Thrombospondin-1 Drives Cardiac Remodeling in Chronic Kidney Disease.  |  Julovi, SM., et al. 2024. JACC Basic Transl Sci. 9: 607-627. PMID: 38984053

The preferred Thrombospondin 1 antibody is Thrombospondin 1 Antibody (A6.1): sc-59887.