Synapsin IIa Antibody (1): sc-136086

Synapsin IIa Antibody (1) is a mouse monoclonal IgG1 kappa light chain antibody that detects Synapsin IIa protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-Synapsin IIa antibody (1) is available as a non-conjugated format. Synapsins are critical synaptic vesicle-associated phosphoproteins that play a vital role in regulating synaptic vesicle exocytosis and are implicated in synaptogenesis, which is essential for proper neuronal communication and plasticity. Synapsin IIa (1) monoclonal antibody recognizes protein primarily located in presynaptic terminals of neurons, where Synapsin IIa facilitates clustering of synaptic vesicles and their release in response to calcium influx. This localization ensures efficient neurotransmitter release during synaptic transmission, influencing synaptic strength and plasticity. Synapsin IIa interacts with various proteins, including actin and other synaptic proteins, which underscores its importance in maintaining synaptic integrity and function. Regulation by calcium and calmodulin highlights Synapsin IIa′s role in dynamic processes of synaptic activity, making Synapsin IIa a key player in intricate signaling pathways governing neuronal communication.

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Synapsin IIa Antibody (1) References:

1. The structure of the human synapsin I gene and protein.  |  Südhof, TC. 1990. J Biol Chem. 265: 7849-52. PMID: 2110562
2. Synapsins: mosaics of shared and individual domains in a family of synaptic vesicle phosphoproteins.  |  Südhof, TC., et al. 1989. Science. 245: 1474-80. PMID: 2506642
3. Temporal onset of synapsin I gene expression coincides with neuronal differentiation during the development of the nervous system.  |  Melloni, RH. and DeGennaro, LJ. 1994. J Comp Neurol. 342: 449-62. PMID: 8021345
4. Ca2+-dependent interaction with calmodulin is conserved in the synapsin family: identification of a high-affinity site.  |  Nicol, S., et al. 1997. Biochemistry. 36: 11487-95. PMID: 9298969
5. Synapsins I and II are ATP-binding proteins with differential Ca2+ regulation.  |  Hosaka, M. and Südhof, TC. 1998. J Biol Chem. 273: 1425-9. PMID: 9430678
6. Synapsin I is structurally similar to ATP-utilizing enzymes.  |  Esser, L., et al. 1998. EMBO J. 17: 977-84. PMID: 9463376
7. A third member of the synapsin gene family.  |  Kao, HT., et al. 1998. Proc Natl Acad Sci U S A. 95: 4667-72. PMID: 9539796
8. Synapsin III, a novel synapsin with an unusual regulation by Ca2+.  |  Hosaka, M. and Südhof, TC. 1998. J Biol Chem. 273: 13371-4. PMID: 9593663

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Synapsin IIa Antibody (1) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Synapsin IIa Antibody (1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Synapsin IIa Antibody (1) Specifications

Alternate Product Name: Synapsin 2

Product Clone Name: 1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 451-586

Epitope Target: Synapsin IIa

Epitope Species: rat

Product Reactivity/Detection: Synapsin IIa

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Synapsin IIa Antibody (1): N/A