Sp2 Antibody (H-9): sc-166575

Sp2 Antibody (H-9) is a mouse monoclonal IgG2b antibody that detects Sp2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Sp2 is a member of the Sp transcription factor family, which also includes Sp1, Sp3, and Sp4, and is characterized by a highly conserved DNA-binding domain featuring three zinc fingers at its C-terminus. This structural feature is crucial as Sp2 binds to specific DNA sequences, although with weaker affinity for GT boxes compared to its family counterparts. Sp2′s interaction with these regulatory elements is significant for gene expression modulation, particularly in the context of neuronal nicotinic acetylcholine receptors, where Sp2′s limited binding capacity may influence overall transcriptional regulation in neuronal tissues. Notably, Sp2 is predominantly expressed in various tissues, but shows particular abundance in the brain, highlighting Sp2′s potential role in neurodevelopment and function. The gene encoding human Sp2 is located on chromosome 17p32.3, and understanding Sp2′s interactions and regulatory mechanisms is essential for elucidating Sp2′s role in cellular processes and potential implications in neurological disorders. Anti-Sp2 antibody (H-9) is an invaluable tool for researchers investigating the complex regulatory networks involving Sp transcription factors and their impact on gene expression.

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Sp2 Antibody (H-9) References:

1. Sp2 is a maternally inherited transcription factor required for embryonic development.  |  Xie, J., et al. 2010. J Biol Chem. 285: 4153-4164. PMID: 19959469
2. Specificity protein 2 (Sp2) is essential for mouse development and autonomous proliferation of mouse embryonic fibroblasts.  |  Baur, F., et al. 2010. PLoS One. 5: e9587. PMID: 20221402
3. Photoredox Catalysis in Nickel-Catalyzed Cross-Coupling.  |  Cavalcanti, LN. and Molander, GA. 2016. Top Curr Chem (Cham). 374: 39. PMID: 27573391
4. Isolation and characterization of a novel phage Xoo-sp2 that infects Xanthomonas oryzae pv. oryzae.  |  Dong, Z., et al. 2018. J Gen Virol. 99: 1453-1462. PMID: 30102145
5. The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.  |  Piskacek, M., et al. 2020. Cell Mol Life Sci. 77: 1793-1810. PMID: 31375868
6. Assessing the oncolytic potential of rotavirus on mouse myeloma cell line Sp2/0-Ag14.  |  Guerrero, RA., et al. 2020. Biomedica. 40: 362-381. PMID: 32673463
7. HNRNPD interacts with ZHX2 regulating the vasculogenic mimicry formation of glioma cells via linc00707/miR-651-3p/SP2 axis.  |  Yu, S., et al. 2021. Cell Death Dis. 12: 153. PMID: 33542193
8. The designed NF-κB inhibitor, DHMEQ, inhibits KISS1R-mediated invasion and increases drug-sensitivity in mouse plasmacytoma SP2/0 cells.  |  Lin, Y., et al. 2021. Exp Ther Med. 22: 1092. PMID: 34504546
9. Transcription Factor SP2 Regulates Ski-mediated Astrocyte Proliferation In Vitro.  |  Da, CM., et al. 2021. Neuroscience. 479: 22-34. PMID: 34687796
10. Complete genome sequence of the cellulolytic planctomycete Telmatocola sphagniphila SP2T and characterization of the first cellulolytic enzyme from planctomycetes.  |  Rakitin, AL., et al. 2021. Syst Appl Microbiol. 44: 126276. PMID: 34735803

The preferred Sp2 antibody is Sp2 Antibody (A-8): sc-17814.