MRP1 Antibody (E-7): sc-365990

MRP1 Antibody (E-7) is a mouse monoclonal IgG3 antibody that detects MRP1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MRP1, or multidrug-resistance protein 1, plays a crucial role in the cellular efflux of various substrates, including drugs and endogenous compounds, thereby contributing to the phenomenon of multidrug resistance in cancer cells. MRP1 is primarily located in the plasma membrane of various cell types, including those in the brain, lungs, and testis, which is significant because MRP1 expression in these tissues can influence drug pharmacokinetics and therapeutic efficacy. MRP1 presence in the blood-brain barrier can limit the effectiveness of chemotherapeutic agents, making MRP1 a critical target for research aimed at overcoming drug resistance in cancer treatment. MRP1′s structure includes an Mdr-like core and a unique N-terminal membrane-bound region, which are essential for MRP1 function as a transporter. Understanding MRP1 dynamics and interactions with other proteins can provide insights into the mechanisms of drug resistance and potential strategies for enhancing drug delivery in resistant tumors. Anti-MRP1 antibody (E-7) is an invaluable tool for researchers investigating these pathways and the broader implications of multidrug resistance in cancer therapy.

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MRP1 Antibody (E-7) References:

1. Potent interaction of flavopiridol with MRP1.  |  Hooijberg, JH., et al. 1999. Br J Cancer. 81: 269-76. PMID: 10496352
2. ATPase activity of purified and reconstituted multidrug resistance protein MRP1 from drug-selected H69AR cells.  |  Mao, Q., et al. 1999. Biochim Biophys Acta. 1461: 69-82. PMID: 10556489
3. Structural, mechanistic and clinical aspects of MRP1.  |  Hipfner, DR., et al. 1999. Biochim Biophys Acta. 1461: 359-76. PMID: 10581367
4. Localization of the GSH-dependent photolabelling site of an agosterol A analog on human MRP1.  |  Ren, XQ., et al. 2003. Br J Pharmacol. 138: 1553-61. PMID: 12721111
5. Targeting an extracellular epitope of the human multidrug resistance protein 1 (MRP1) in malignant cells with a novel recombinant single chain Fv antibody.  |  Binyamin, L., et al. 2004. Int J Cancer. 110: 882-90. PMID: 15170671
6. Probing ATP-dependent conformational changes in the multidrug resistance protein 1 (MRP1/ABCC1) in live tumor cells with a novel recombinant single-chain Fv antibody targeted to the extracellular N-terminus.  |  Binyamin, L., et al. 2005. Int J Cancer. 116: 703-9. PMID: 15838832
7. Mrp1 localization and function in cardiac mitochondria after doxorubicin.  |  Jungsuwadee, P., et al. 2009. Mol Pharmacol. 75: 1117-26. PMID: 19233900
8. Nuclear translocation of MRP1 contributes to multidrug resistance of mucoepidermoid carcinoma.  |  Cai, BL., et al. 2011. Oral Oncol. 47: 1134-40. PMID: 21903448
9. MRP1-targeted near infrared photoimmunotherapy for drug resistant small cell lung cancer.  |  Li, F., et al. 2021. Int J Pharm. 604: 120760. PMID: 34077781
10. Combinatory therapy of MRP1-targeted photoimmunotherapy and liposomal doxorubicin promotes the antitumor effect for chemoresistant small cell lung cancer.  |  Li, F., et al. 2022. Int J Pharm. 625: 122076. PMID: 35931394

The preferred MRP1 antibody is MRP1 Antibody (QCRL-1): sc-18835.