MCM3 Antibody (E-7): sc-365616

MCM3 Antibody (E-7) is a mouse monoclonal IgG1 antibody that detects MCM3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MCM3, a member of the mini-chromosome maintenance (MCM) protein family, plays a crucial role in the regulation of DNA replication, ensuring that DNA is replicated only once per cell cycle. Anti-MCM3 antibody (E-7) helps researchers study genomic stability and prevent over-replication, which can lead to genomic instability and cancer. MCM3 is located in the nucleus, where MCM3 forms part of the MCM2-7 complex, which acts as a helicase to unwind DNA during replication. The proper functioning of MCM3 and associated proteins is essential for the initiation of DNA synthesis, and any dysregulation can have significant implications for cell proliferation and tumorigenesis. MCM3 is also subject to post-translational modifications, which can influence MCM3 activity and interactions with other proteins, further underscoring MCM3′s importance in cellular processes. MCM3 (E-7) antibody serves as an invaluable tool for researchers studying the mechanisms of DNA replication and the role of MCM proteins in cell cycle regulation.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

MCM3 Antibody (E-7) References:

1. MCM3: A Novel Proliferation Marker in Oral Squamous Cell Carcinoma.  |  Valverde, LF., et al. 2018. Appl Immunohistochem Mol Morphol. 26: 120-125. PMID: 27258565
2. MCM3 and Ki67 proliferation markers in odontogenic cysts and ameloblastoma.  |  Jaafari-Ashkavandi, Z., et al. 2019. J Oral Biol Craniofac Res. 9: 47-50. PMID: 30225187
3. Bioinformatics Analysis Reveals MCM3 as an Important Prognostic Marker in Cervical Cancer.  |  Ma, H., et al. 2021. Comput Math Methods Med. 2021: 8494260. PMID: 34671420
4. MCM3 is a novel proliferation marker associated with longer survival for patients with tubo-ovarian high-grade serous carcinoma.  |  Kang, EY., et al. 2022. Virchows Arch. 480: 855-871. PMID: 34782936
5. Systematic analysis of MCM3 in pediatric medulloblastoma via multi-omics analysis.  |  Liang, Z., et al. 2022. Front Mol Biosci. 9: 815260. PMID: 36133906
6. Pyrroloquinoline quinone alleviates natural aging-related osteoporosis via a novel MCM3-Keap1-Nrf2 axis-mediated stress response and Fbn1 upregulation.  |  Li, J., et al. 2023. Aging Cell. 22: e13912. PMID: 37365714
7. m6A demethylase FTO stabilizes LINK-A to exert oncogenic roles via MCM3-mediated cell-cycle progression and HIF-1α activation.  |  Nan, Y., et al. 2023. Cell Rep. 42: 113273. PMID: 37858471
8. LncRNA GAS6-AS1 contributes to 5-fluorouracil resistance in colorectal cancer by facilitating the binding of PCBP1 with MCM3.  |  Zhu, Z., et al. 2024. Cancer Lett. 589: 216828. PMID: 38521199
9. The prognostic and immunological role of MCM3 in pan-cancer and validation of prognosis in a clinical lower-grade glioma cohort.  |  Huang, QR., et al. 2024. Front Pharmacol. 15: 1390615. PMID: 38698811
10. Expression, potential biological behaviour and clinical significance of MCM3 in pancreatic adenocarcinoma: a comprehensive study integrating high throughput sequencing, CRISPR screening and in-house immunohistochemistry.  |  Chen, Y., et al. 2024. Ann Med. 56: 2405879. PMID: 39310930

The preferred MCM3 antibody is MCM3 Antibody (E-8): sc-390480.