KCTD14 Antibody (A-12): sc-393889

KCTD14 Antibody (A-12) is a mouse monoclonal IgG1 antibody that detects KCTD14 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KCTD14, or potassium channel tetramerisation domain containing 14, is a 255 amino acid protein characterized by the presence of a BTB (Broad-Complex, Tramtrack and Bric a brac) domain, which plays a crucial role in the regulation of transcription by influencing chromatin structure and function. This protein is encoded by a gene located on human chromosome 11, a region that is significant due to its association with various genetic disorders, including Jervell and Lange-Nielsen syndrome and Jacobsen syndrome, highlighting the importance of KCTD14 in maintaining cellular homeostasis and proper physiological function. The presence of the BTB domain in KCTD14 suggests involvement in protein-protein interactions that are essential for the assembly and function of potassium channels, which are vital for maintaining the electrical excitability of cells. Anti-KCTD14 antibody (A-12) is an invaluable tool for researchers investigating the molecular mechanisms underlying these critical processes and the pathogenesis of related diseases.

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KCTD14 Antibody (A-12) References:

1. Targeted disruption of the mouse testis-enriched gene Znf230 does not affect spermatogenesis or fertility.  |  Liu, Y., et al. 2014. Genet Mol Biol. 37: 708-15. PMID: 25505846
2. NAC1 Regulates Somatic Cell Reprogramming by Controlling Zeb1 and E-cadherin Expression.  |  Faiola, F., et al. 2017. Stem Cell Reports. 9: 913-926. PMID: 28781078
3. KCTD: A new gene family involved in neurodevelopmental and neuropsychiatric disorders.  |  Teng, X., et al. 2019. CNS Neurosci Ther. 25: 887-902. PMID: 31197948
4. Network meta-analysis of transcriptome expression changes in different manifestations of dengue virus infection.  |  Winter, C., et al. 2022. BMC Genomics. 23: 165. PMID: 35220956
5. Cancer-associated fibroblast-derived gene signatures predict radiotherapeutic survival in prostate cancer patients.  |  Zhang, R. and Liu, F. 2022. J Transl Med. 20: 453. PMID: 36195908
6. Alphafold Predictions Provide Insights into the Structural Features of the Functional Oligomers of All Members of the KCTD Family.  |  Esposito, L., et al. 2022. Int J Mol Sci. 23: PMID: 36362127
7. A novel DNA methylation-related gene signature for the prediction of overall survival and immune characteristics of ovarian cancer patients.  |  Wang, S., et al. 2023. J Ovarian Res. 16: 62. PMID: 36978087
8. An intellectual-disability-associated mutation of the transcriptional regulator NACC1 impairs glutamatergic neurotransmission.  |  Daniel, JA., et al. 2023. Front Mol Neurosci. 16: 1115880. PMID: 37533751
9. Unraveling potential gene biomarkers for dengue infection through RNA sequencing.  |  Suppiah, J., et al. 2025. Virus Genes. 61: 26-37. PMID: 39397194
10. Hormonally-regulated KCTD14 Expression Is Higher in Oocytes from Antral Follicles Compared to Those from Preantral Follicles in Mice, with Implications in Fertility.  |  Berkel, C. 2025. Reprod Sci.. PMID: 40044995

The preferred KCTD14 antibody is KCTD14 Antibody (A-6): sc-393876.