Integrin αIIb/ITGA2B/CD41 Antibody (B-10): sc-166599

Integrin αIIb Antibody (B-10) is a mouse monoclonal IgG2b antibody that detects Integrin αIIb in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Integrin αIIb is a crucial component of the integrin family, primarily expressed on platelets, where anti-Integrin αIIb antibody (B-10) plays a vital role in hemostasis and thrombosis by mediating platelet aggregation. This protein forms a heterodimer with the β3 subunit, resulting in the integrin αIIbβ3 complex, which is essential for binding to fibrinogen and other extracellular matrix proteins. The ability of Integrin αIIb to interact with these ligands is critical for the formation of stable platelet aggregates, which is necessary for proper blood clotting and wound healing. Dysregulation of Integrin αIIb function can lead to various bleeding disorders, highlighting its importance in maintaining vascular integrity. Integrin αIIb monoclonal antibody (B-10) is an invaluable tool for researchers studying platelet biology, cardiovascular diseases, and the mechanisms of thrombosis, providing insights into the therapeutic targeting of integrin pathways.

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Integrin αIIb/ITGA2B/CD41 Antibody (B-10) References:

1. Integrin alphaIIb promoter-targeted expression of gene products in megakaryocytes derived from retrovirus-transduced human hematopoietic cells.  |  Wilcox, DA., et al. 1999. Proc Natl Acad Sci U S A. 96: 9654-9. PMID: 10449749
2. Calcium-dependent properties of CIB binding to the integrin alphaIIb cytoplasmic domain and translocation to the platelet cytoskeleton.  |  Shock, DD., et al. 1999. Biochem J. 342 Pt 3: 729-35. PMID: 10477286
3. Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3.  |  Li, Z., et al. 2006. Blood. 107: 965-72. PMID: 16210341
4. Identification of residues of functional importance within the central turn motifs present in the cytoplasmic tails of integrin alphaIIb and alphaV subunits.  |  Haas, TA., et al. 2008. Thromb Res. 122: 507-16. PMID: 18328539
5. A novel Pro126His beta propeller mutation in integrin alphaIIb causes Glanzmann thrombasthenia by impairing progression of pro-alphaIIbbeta3 from endoplasmic reticulum to Golgi.  |  Shen, WZ., et al. 2009. Blood Cells Mol Dis. 42: 44-50. PMID: 18976939
6. In silico analysis of structural modifications in and around the integrin αIIb genu caused by ITGA2B variants in human platelets with emphasis on Glanzmann thrombasthenia.  |  Pillois, X., et al. 2018. Mol Genet Genomic Med. 6: 249-260. PMID: 29385657
7. Critical residues of integrin alphaIIb subunit for binding of alphaIIbbeta3 (glycoprotein IIb-IIIa) to fibrinogen and ligand-mimetic antibodies (PAC-1, OP-G2, and LJ-CP3).  |  Kamata, T., et al. 1996. J Biol Chem. 271: 18610-5. PMID: 8702512
8. A molecular basis for affinity modulation of Fab ligand binding to integrin alphaIIb beta3.  |  Kunicki, TJ., et al. 1996. J Biol Chem. 271: 20315-21. PMID: 8702765
9. Ectopic expression of platelet integrin alphaIIb beta3 in tumor cells from various species and histological origin.  |  Chen, YQ., et al. 1997. Int J Cancer. 72: 642-8. PMID: 9259405
10. Complementary roles for receptor clustering and conformational change in the adhesive and signaling functions of integrin alphaIIb beta3.  |  Hato, T., et al. 1998. J Cell Biol. 141: 1685-95. PMID: 9647659

The preferred Integrin αIIb/ITGA2B/CD41 antibody is Integrin αIIb/ITGA2B/CD41 Antibody (MWReg30): sc-19963.