Integrin αIIb/ITGA2B/CD41 Antibody (96-2C1): sc-21773
- Integrin αIIb/ITGA2B/CD41 Antibody (96-2C1) is a mouse monoclonal IgG1 κ, cited in 7 publications, provided at 200 µg/ml
- raised against Integrin αIIb from PBL cells of human origin
- recommended for detection of Integrin αIIb of mouse, rat and human origin by WB, IP and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- See Integrin αIIb/ITGA2B/CD41 (B-9): sc-365938 for Integrin αIIb/ITGA2B/CD41 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Integrin αIIb/ITGA2B/CD41 Antibody (96-2C1) for WB applications. These reagents are now offered in bundles with Integrin αIIb/ITGA2B/CD41 Antibody (96-2C1) (see ordering information below).
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Integrin αIIb Antibody (96-2C1) is a mouse monoclonal IgG1 antibody that detects Integrin αIIb in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and flow cytometry (FCM). Integrin αIIb plays a crucial role in platelet aggregation and is essential for hemostasis, as anti-Integrin αIIb antibody (96-2C1) recognizes the protein that forms a heterodimer with the β3 subunit to create integrin αIIbβ3, also known as glycoprotein IIb/IIIa. Integrin αIIb is primarily located on the surface of platelets and is responsible for binding fibrinogen and other adhesive proteins, facilitating the cross-linking of platelets during clot formation. Proper functioning of Integrin αIIb is vital for maintaining normal blood clotting processes; any dysfunction can lead to bleeding disorders such as Glanzmann thrombasthenia. Furthermore, Integrin αIIb undergoes various post-translational modifications, including glycosylation, which can influence activity and interactions with ligands. Integrin αIIb monoclonal antibody (96-2C1) is an invaluable tool for researchers studying platelet biology, thrombus formation, and related cardiovascular diseases, providing insights into the mechanisms of integrin-mediated signaling and cell adhesion.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Integrin αIIb/ITGA2B/CD41 Antibody (96-2C1) References:
- Divalent cations differentially regulate integrin alphaIIb cytoplasmic tail binding to beta3 and to calcium- and integrin-binding protein. | Vallar, L., et al. 1999. J Biol Chem. 274: 17257-66. PMID: 10358085
- Dimerization of the transmembrane domain of Integrin alphaIIb subunit in cell membranes. | Li, R., et al. 2004. J Biol Chem. 279: 26666-73. PMID: 15067009
- Protein phosphatase 1 associates with the integrin alphaIIb subunit and regulates signaling. | Vijayan, KV., et al. 2004. J Biol Chem. 279: 33039-42. PMID: 15205468
- Novel pathway for megakaryocyte production after in vivo conditional eradication of integrin alphaIIb-expressing cells. | Jacquelin, B., et al. 2005. Blood. 106: 1965-74. PMID: 15947096
- Integrin alphaIIb-subunit cytoplasmic domain mutations demonstrate a requirement for tyrosine phosphorylation of beta3-subunits in actin cytoskeletal organization. | Yamodo, IH. and Blystone, SD. 2004. Cell Commun Adhes. 11: 121-35. PMID: 16194880
- A palmitoylated peptide, derived from the acidic carboxyl-terminal segment of the integrin alphaIIb cytoplasmic domain, inhibits platelet activation. | Koloka, V., et al. 2008. Platelets. 19: 502-11. PMID: 18979362
- Multiple approaches converge on the structure of the integrin alphaIIb/beta3 transmembrane heterodimer. | Metcalf, DG., et al. 2009. J Mol Biol. 392: 1087-101. PMID: 19527732
- Three-dimensional model of human platelet integrin alphaIIb beta3 in solution obtained by small angle neutron scattering. | Nogales, A., et al. 2010. J Biol Chem. 285: 1023-31. PMID: 19897481
- Control of integrin alphaIIb beta3 outside-in signaling and platelet adhesion by sensing the physical properties of fibrin(ogen) substrates. | Podolnikova, NP., et al. 2010. Biochemistry. 49: 68-77. PMID: 19929007
- Solution structures of Ca2+-CIB1 and Mg2+-CIB1 and their interactions with the platelet integrin alphaIIb cytoplasmic domain. | Huang, H., et al. 2011. J Biol Chem. 286: 17181-92. PMID: 21388953
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Integrin αIIb/ITGA2B/CD41 Antibody (96-2C1) | sc-21773 | 200 µg/ml | $322.00 | |||
Integrin αIIb/ITGA2B/CD41 Antibody (96-2C1): m-IgG Fc BP-HRP Bundle | sc-536667 | 200 µg Ab; 10 µg BP | $361.00 | |||
Integrin αIIb/ITGA2B/CD41 Antibody (96-2C1): m-IgGκ BP-HRP Bundle | sc-533826 | 200 µg Ab; 40 µg BP | $361.00 | |||
Integrin αIIb/ITGA2B/CD41 Antibody (96-2C1): m-IgG1 BP-HRP Bundle | sc-544750 | 200 µg Ab; 20 µg BP | $361.00 | |||
Integrin αIIb/ITGA2B/CD41 Antibody (96-2C1) FITC | sc-21773 FITC | 200 µg/ml | $336.00 | |||
Integrin αIIb/ITGA2B/CD41 Antibody (96-2C1) PE | sc-21773 PE | 200 µg/ml | $349.00 |