IL-17 Antibody (1): sc-53937

IL-17 Antibody (1) is a mouse monoclonal IgG2b kappa light chain antibody raised against full-length human interleukin-17 (IL-17), also known as IL-17A or CTLA8. IL-17 is a pro-inflammatory cytokine predominantly produced by activated T helper 17 (Th17) cells and plays a crucial role in immune regulation and inflammatory responses. IL-17 is a secreted protein located in the extracellular space, which is essential for its function as IL-17 interacts with its receptor, IL-17R, on various target cells to initiate signal transduction cascades. This extracellular localization facilitates the mediation of communication between immune cells and contributes to the coordination of defense mechanisms against pathogens. Dysregulation of IL-17 expression is associated with autoimmune and inflammatory diseases such as psoriasis, rheumatoid arthritis, and multiple sclerosis. Anti-IL-17 antibody (1) specifically reacts with human IL-17 in western blotting (WB) and enzyme-linked immunosorbent assay (ELISA) applications, making anti-IL-17 antibody (1) a valuable tool for researchers studying IL-17′s role in human immune responses and disease pathogenesis. Anti-IL-17 antibody (1) aids in the exploration of therapeutic strategies aimed at modulating inflammatory processes and developing treatments for autoimmune conditions.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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IL-17 Antibody (1) References:

1. IL-17 cytokine family.  |  Kawaguchi, M., et al. 2004. J Allergy Clin Immunol. 114: 1265-73; quiz 1274. PMID: 15577820
2. IL-17: overview and role in oral immunity and microbiome.  |  Abusleme, L. and Moutsopoulos, NM. 2017. Oral Dis. 23: 854-865. PMID: 27763707
3. The Impact of IL-17 in Atherosclerosis.  |  Lu, X. 2017. Curr Med Chem. 24: 2345-2358. PMID: 28425862
4. IL-17 in Renal Immunity and Autoimmunity.  |  Biswas, PS. 2018. J Immunol. 201: 3153-3159. PMID: 30455371
5. Systemic effects of IL-17 in inflammatory arthritis.  |  Beringer, A. and Miossec, P. 2019. Nat Rev Rheumatol. 15: 491-501. PMID: 31227819
6. The IL-23-IL-17 pathway as a therapeutic target in axial spondyloarthritis.  |  Sieper, J., et al. 2019. Nat Rev Rheumatol. 15: 747-757. PMID: 31551538
7. Critical role of interleukin (IL)-17 in inflammatory and immune disorders: An updated review of the evidence focusing in controversies.  |  Ruiz de Morales, JMG., et al. 2020. Autoimmun Rev. 19: 102429. PMID: 31734402
8. Cytokines of the IL-17 family in psoriasis.  |  Lauffer, F., et al. 2020. J Dtsch Dermatol Ges. 18: 675-681. PMID: 32447845
9. IL-17 promotes osteoclast-induced bone loss by regulating glutamine-dependent energy metabolism.  |  Peng, R., et al. 2024. Cell Death Dis. 15: 111. PMID: 38316760
10. IL-17 in skin infections and homeostasis.  |  García-Patiño, MG., et al. 2024. Clin Immunol. 267: 110352. PMID: 39218195

The preferred IL-17 antibody is IL-17 Antibody (G-4): sc-374218.