IFN-γ/Interferon gamma Antibody (4S.B3): sc-47700

IFN-γ Antibody (4S.B3) is a mouse monoclonal IgG1 antibody that detects Interferon gamma (IFN-γ) in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). IFN-γ plays a crucial role in the immune response, acting as a potent antiviral and antiparasitic agent produced by activated CD4+/CD8+ lymphocytes and natural killer cells. Anti-IFN-γ antibody (4S.B3) helps researchers study how IFN-γ modulates T cell growth and differentiation while inhibiting B cell proliferation, thereby shaping the adaptive immune response. IFN-γ′s active form is a homodimer, with each subunit comprising six helices, and this dimeric structure is stabilized by non-covalent interactions at the interface of the helices. The precursor of IFN-γ consists of 166 amino acids, which includes a 23 amino acid secretory sequence, and IFN-γ′s functionality is further enhanced by various post-translational modifications, including glycosylation, leading to multiple forms under non-denaturing conditions, such as dimers and tetramers. The versatility of IFN-γ in immune regulation underscores its significance in therapeutic applications and research, making IFN-γ monoclonal antibody (4S.B3) an essential tool for studying immune responses in human samples.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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IFN-γ/Interferon gamma Antibody (4S.B3) References:

1. Biologic functions of the IFN-gamma receptors.  |  Tau, G. and Rothman, P. 1999. Allergy. 54: 1233-51. PMID: 10688427
2. The role of IFN-gamma in the outcome of chlamydial infection.  |  Rottenberg, ME., et al. 2002. Curr Opin Immunol. 14: 444-51. PMID: 12088678
3. Paradoxical roles of IFN-gamma in models of Th1-mediated autoimmunity.  |  Rosloniec, EF., et al. 2002. Arthritis Res. 4: 333-6. PMID: 12453308
4. The untold story of IFN-γ in cancer biology.  |  Kursunel, MA. and Esendagli, G. 2016. Cytokine Growth Factor Rev. 31: 73-81. PMID: 27502919
5. IFN-γ and CD38 in Hyperprogressive Cancer Development.  |  Angelicola, S., et al. 2021. Cancers (Basel). 13: PMID: 33467713
6. IFN-γ(g)uarding the niche-Keeping ILC2 in check.  |  Smole, U. and Hammad, H. 2022. Immunity. 55: 190-192. PMID: 35139347
7. IFN-γ Contributes to the Immune Mechanisms of Hypertension.  |  Benson, LN., et al. 2022. Kidney360. 3: 2164-2173. PMID: 36591357
8. Inborn errors of human transcription factors governing IFN-γ antimycobacterial immunity.  |  Ogishi, M., et al. 2023. Curr Opin Immunol. 81: 102296. PMID: 36867972
9. AMG487 alleviates influenza A (H1N1) virus-induced pulmonary inflammation through decreasing IFN-γ-producing lymphocytes and IFN-γ concentrations.  |  Ding, W., et al. 2024. Br J Pharmacol. 181: 2053-2069. PMID: 38500396
10. Ebi3 Binding to IFN-γ and IL-10 Limits Their Function.  |  Scott, EN., et al. 2024. J Immunol. 213: 1115-1124. PMID: 39240167

The preferred IFN-γ/Interferon gamma antibody is IFN-γ/Interferon gamma Antibody (G-23): sc-8423.