IFN-γ/Interferon gamma Antibody (3F1E3): sc-32813

IFN-γ Antibody (3F1E3) is a mouse monoclonal IgG1 antibody that detects Interferon (IFN)-γ in human samples through applications such as western blotting (WB) and immunoprecipitation (IP). IFN-γ plays a crucial role in the immune response, acting as an antiviral and antiparasitic agent produced by activated CD4+/CD8+ lymphocytes and natural killer cells. Production of IFN-γ is stimulated by various factors, including antigens, mitogens, and alloantigens, and proves essential for modulating T cell growth and differentiation while inhibiting B cell proliferation. IFN-γ′s active form is a homodimer, with each subunit comprising six helices, and this dimeric structure is stabilized by non-covalent interactions at the helices′ interface. The significance of IFN-γ′s structure lies in its ability to effectively bind to its receptor, initiating a cascade of immune responses vital for combating infections and regulating immune functions. The precursor of IFN-γ consists of 166 amino acids, which includes a 23 amino acid secretory sequence, and IFN-γ′s functionality is further diversified by variable glycosylation and the formation of dimers and tetramers under non-denaturing conditions. With a critical role in immune regulation and response, anti-IFN-γ antibody (3F1E3) serves as an invaluable tool for researchers studying immune mechanisms and therapeutic interventions.

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Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

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IFN-γ/Interferon gamma Antibody (3F1E3) References:

1. Escape from IFN-γ-dependent immunosurveillance in tumorigenesis.  |  Lin, CF., et al. 2017. J Biomed Sci. 24: 10. PMID: 28143527
2. RNAi-based modulation of IFN-γ signaling in skin.  |  Tang, Q., et al. 2022. Mol Ther. 30: 2709-2721. PMID: 35477658
3. Role of interferon-gamma (IFN-γ) and IFN-γ receptor 1/2 (IFNγR1/2) in regulation of immunity, infection, and cancer development: IFN-γ-dependent or independent pathway.  |  Ding, H., et al. 2022. Biomed Pharmacother. 155: 113683. PMID: 36095965
4. Inherited human ITK deficiency impairs IFN-γ immunity and underlies tuberculosis.  |  Ogishi, M., et al. 2023. J Exp Med. 220: PMID: 36326697
5. Double-barrel targeting of IFN-γ to treat hemophagocytic lymphohistiocytosis.  |  Cron, RQ. 2023. J Allergy Clin Immunol. 151: 106-107. PMID: 36347304
6. Dysregulation in IFN-γ signaling and response: the barricade to tumor immunotherapy.  |  Han, J., et al. 2023. Front Immunol. 14: 1190333. PMID: 37275859
7. NIR-responsive copper nanoliposome composites for cascaded ferrotherapy via ferroptosis actived ICD and IFN-γ released.  |  Wang, J., et al. 2024. Biomaterials. 308: 122570. PMID: 38636133
8. Priming of hippocampal microglia by IFN-γ/STAT1 pathway impairs social memory in mice.  |  He, H., et al. 2024. Int Immunopharmacol. 134: 112191. PMID: 38759369
9. IFN-γ stimulates Paneth cell secretion through necroptosis mTORC1 dependent.  |  Encarnacion-Garcia, MR., et al. 2024. Eur J Immunol. 54: e2350716. PMID: 38837757
10. Building a novel TRUCK by harnessing the endogenous IFN-gamma promoter for cytokine expression.  |  Ma, L., et al. 2024. Mol Ther. 32: 2728-2740. PMID: 38879754

The preferred IFN-γ/Interferon gamma antibody is IFN-γ/Interferon gamma Antibody (G-23): sc-8423.