Flg/FGFR1 Antibody (M5G10): sc-57133
- Flg/FGFR1 Antibody (M5G10) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against the ectodomain of Flg of human origin
- recommended for detection of Flg isoforms α and β of mouse, rat and human origin by WB, IP, IF and IHC(P)
- See Flg/FGFR1 (M2F12): sc-57132 for Flg/FGFR1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Flg/FGFR1 Antibody (M5G10) for WB and IHC(P) applications. These reagents are now offered in bundles with Flg/FGFR1 Antibody (M5G10) (see ordering information below).
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Flg Antibody (M5G10) is a mouse monoclonal IgG1 antibody that detects Flg in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Flg, or fibroblast growth factor receptor 1, plays a crucial role in cellular processes, including proliferation, differentiation, and survival, by binding to various fibroblast growth factors. This interaction is vital for normal development and tissue repair, as fibroblast growth factors are key regulators of angiogenesis and wound healing. Flg protein is primarily located on the cell surface, where Flg interacts with ligands, initiating a cascade of intracellular signaling pathways that influence cell behavior. Proper functioning of Flg is essential for maintaining homeostasis in various tissues, and dysregulation can lead to severe developmental disorders, such as Pfeiffer syndrome, characterized by craniosynostosis and skeletal abnormalities. Mutations in Flg have been implicated in chromosomal translocations associated with stem cell leukemia lymphoma, highlighting Flg′s significance in both normal physiology and disease pathology. Anti-Flg antibody (M5G10) provides a reliable tool for researchers investigating the role of this critical protein in various biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Flg/FGFR1 Antibody (M5G10) References:
- Fibroblast growth factor receptor-1 interacts with the T-cell receptor signalling pathway. | Byrd, VM., et al. 2003. Immunol Cell Biol. 81: 440-50. PMID: 14636241
- Fibroblast growth factor receptor 1 as a target for the therapy of renal cell carcinoma. | Tsimafeyeu, I. and Bratslavsky, G. 2015. Oncology. 88: 321-31. PMID: 25678187
- Fibroblast Growth Factor Receptor 1 Drives the Metastatic Progression of Prostate Cancer. | Labanca, E., et al. 2022. Eur Urol Oncol. 5: 164-175. PMID: 34774481
- Fibroblast Growth Factor Receptor 1-4 Genetic Aberrations as Clinically Relevant Biomarkers in Squamous Cell Lung Cancer. | Moes-Sosnowska, J. and Chorostowska-Wynimko, J. 2022. Front Oncol. 12: 780650. PMID: 35402233
- Nuclear Localization of Fibroblast Growth Factor Receptor 1 in Breast Cancer Cells Interacting with Cancer Associated Fibroblasts. | Suh, J., et al. 2022. J Cancer Prev. 27: 68-76. PMID: 35419302
- Fibroblast growth factor receptor 1-bound extracellular vesicle as novel therapy for osteoarthritis. | de Liyis, BG., et al. 2022. Biomedicine (Taipei). 12: 1-9. PMID: 35836973
- Pan-tumor landscape of fibroblast growth factor receptor 1-4 genomic alterations. | Murugesan, K., et al. 2022. ESMO Open. 7: 100641. PMID: 36462464
- Fibroblast growth factor receptor 1 as a potential marker of terminal effector peripheral T helper cells in rheumatoid arthritis patients. | Etori, K., et al. 2023. Rheumatology (Oxford). 62: 3763-3769. PMID: 37184877
- Exploiting the fibroblast growth factor receptor-1 vulnerability to therapeutically restrict the MYC-EZH2-CDKN1C axis-driven proliferation in Mantle cell lymphoma. | Sircar, A., et al. 2023. Leukemia. 37: 2094-2106. PMID: 37598282
- Fibroblast growth factor receptor 1 inhibition suppresses pancreatic cancer chemoresistance and chemotherapy-driven aggressiveness. | Lin, Q., et al. 2024. Drug Resist Updat. 73: 101064. PMID: 38387284
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Flg/FGFR1 Antibody (M5G10) | sc-57133 | 200 µg/ml | $322.00 | |||
Flg/FGFR1 Antibody (M5G10): m-IgG Fc BP-HRP Bundle | sc-537135 | 200 µg Ab; 10 µg BP | $361.00 | |||
Flg/FGFR1 Antibody (M5G10): m-IgGκ BP-HRP Bundle | sc-534327 | 200 µg Ab; 40 µg BP | $361.00 | |||
Flg/FGFR1 Antibody (M5G10): m-IgG1 BP-HRP Bundle | sc-545026 | 200 µg Ab; 20 µg BP | $361.00 |