Dyrk4 Antibody (E-2): sc-390973
- Dyrk4 Antibody (E-2) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 119-219 mapping within an internal region of Dyrk4 of mouse origin
- Anti-Dyrk4 Antibody (E-2) is recommended for detection of Dyrk4 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Dyrk4 Antibody (E-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for Dyrk4 Antibody (E-2) for WB applications. This reagent is now offered in a bundle with Dyrk4 Antibody (E-2) (see ordering information below).
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Dyrk4 Antibody (E-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Dyrk4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Dyrk4 (E-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Dyrk4, a member of the dual specificity tyrosine phosphorylation regulated kinase family, plays a crucial role in cellular signaling pathways, particularly in neurogenesis and spermatogenesis regulation. Dyrk4 is predominantly expressed in post-meiotic spermatids, highlighting its importance in male reproductive biology, and exists in two isoforms, Dyrk4A and Dyrk4B, which exhibit over 95% sequence homology. Dyrk4 is involved in phosphorylating specific substrates essential for proper cellular function and differentiation, and Dyrk4 deficiency has shown no significant impact on male fertility, suggesting potential redundancy in the spermiogenesis pathway. Dyrk4′s interaction with other proteins within the Dyrk family, such as Dyrk1A and Dyrk2, further emphasizes Dyrk4′s role in a complex network of signaling pathways that regulate various cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Dyrk4 Antibody (E-2) References:
- The expression of the testis-specific Dyrk4 kinase is highly restricted to step 8 spermatids but is not required for male fertility in mice. | Sacher, F., et al. 2007. Mol Cell Endocrinol. 267: 80-8. PMID: 17292540
- Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation. | Göckler, N., et al. 2009. FEBS J. 276: 6324-37. PMID: 19796173
- Splice variants of the dual specificity tyrosine phosphorylation-regulated kinase 4 (DYRK4) differ in their subcellular localization and catalytic activity. | Papadopoulos, C., et al. 2011. J Biol Chem. 286: 5494-505. PMID: 21127067
- Dyrk kinases regulate phosphorylation of doublecortin, cytoskeletal organization, and neuronal morphology. | Slepak, TI., et al. 2012. Cytoskeleton (Hoboken). 69: 514-27. PMID: 22359282
- Computational & experimental evaluation of the structure/activity relationship of β-carbolines as DYRK1A inhibitors. | Drung, B., et al. 2014. Bioorg Med Chem Lett. 24: 4854-60. PMID: 25240617
- A Novel Neoplastic Fusion Transcript, RAD51AP1-DYRK4, Confers Sensitivity to the MEK Inhibitor Trametinib in Aggressive Breast Cancers. | Liu, CC., et al. 2021. Clin Cancer Res. 27: 785-798. PMID: 33172895
- Protein quality control of DYRK family protein kinases by the Hsp90-Cdc37 molecular chaperone. | Miyata, Y. and Nishida, E. 2021. Biochim Biophys Acta Mol Cell Res. 1868: 119081. PMID: 34147560
- Are cis-spliced fusion proteins pathological in more aggressive luminal breast cancer? | Liu, CC. and Wang, XS. 2023. Oncotarget. 14: 595-596. PMID: 37306551
- Hypomethylation of DYRK4 in peripheral blood is associated with increased lung cancer risk. | Qiao, R., et al. 2023. Mol Carcinog. 62: 1745-1754. PMID: 37530470
- DYRK4 upregulates antiviral innate immunity by promoting IRF3 activation. | Zeng, X., et al. 2025. EMBO Rep. 26: 690-719. PMID: 39702801
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dyrk4 Antibody (E-2) | sc-390973 | 200 µg/ml | $322.00 | |||
Dyrk4 Antibody (E-2): m-IgG Fc BP-HRP Bundle | sc-526212 | 200 µg Ab; 10 µg BP | $361.00 | |||
Dyrk4 Antibody (E-2) AC | sc-390973 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Dyrk4 Antibody (E-2) HRP | sc-390973 HRP | 200 µg/ml | $322.00 | |||
Dyrk4 Antibody (E-2) FITC | sc-390973 FITC | 200 µg/ml | $336.00 | |||
Dyrk4 Antibody (E-2) PE | sc-390973 PE | 200 µg/ml | $349.00 | |||
Dyrk4 Antibody (E-2) Alexa Fluor® 488 | sc-390973 AF488 | 200 µg/ml | $364.00 | |||
Dyrk4 Antibody (E-2) Alexa Fluor® 546 | sc-390973 AF546 | 200 µg/ml | $364.00 | |||
Dyrk4 Antibody (E-2) Alexa Fluor® 594 | sc-390973 AF594 | 200 µg/ml | $364.00 | |||
Dyrk4 Antibody (E-2) Alexa Fluor® 647 | sc-390973 AF647 | 200 µg/ml | $364.00 | |||
Dyrk4 Antibody (E-2) Alexa Fluor® 680 | sc-390973 AF680 | 200 µg/ml | $364.00 | |||
Dyrk4 Antibody (E-2) Alexa Fluor® 790 | sc-390973 AF790 | 200 µg/ml | $364.00 |