CASKIN2 Antibody (E-10): sc-393793

CASKIN2 Antibody (E-10) is a mouse monoclonal IgG2a antibody that detects CASKIN2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CASKIN2, also known as ANKS5B, is a 1,202 amino acid protein that plays a crucial role in cellular signaling by interacting with CASK, a scaffolding protein essential for linking various signaling pathways. The presence of one SH3 domain, two SAM domains, and six ANK repeats in CASKIN2 suggests a complex structural organization that facilitates interactions with other proteins, thereby influencing downstream signaling events. CASKIN2 is predominantly localized in the cytoplasm and is expressed ubiquitously, with highest levels found in fetal and adult liver tissues, indicating importance in liver function and development. The gene encoding CASKIN2 is located on human chromosome 17, a region significant not only for high gene density but also for association with critical tumor suppressor genes such as p53 and BRCA1, which are vital for maintaining genomic stability and preventing cancer. Anti-CASKIN2 antibody (E-10) serves as an essential tool for researchers studying CASK function modulation and interactions with other signaling molecules, highlighting CASKIN2′s potential role in various physiological processes and cancer biology.

The preferred CASKIN2 antibody is CASKIN2 Antibody (D-9): sc-377512.