Wip1 Activators
Common Wip1 Activators include, but are not limited to Doxorubicin CAS 23214-92-8, Fluorouracil CAS 51-21-8, Nutlin-3 CAS 548472-68-0, Camptothecin CAS 7689-03-4 and Etoposide (VP-16) CAS 33419-42-0.
Wip1, also known as Wild-type p53-induced phosphatase 1 or PPM1D, is a serine/threonine phosphatase that has garnered significant attention for its role in cellular stress responses, particularly in the context of DNA damage repair and cell cycle regulation. Wip1 acts as a negative regulator of the p53 pathway, a central signaling cascade that orchestrates cellular responses to DNA damage. Upon activation due to cellular stress, Wip1 dephosphorylates several targets in the p53 pathway, including p53 itself, leading to its inactivation. This ensures that the DNA damage response is transient and gets turned off once the damage is repaired. By modulating the activity of p53 and other associated proteins, Wip1 plays a pivotal role in maintaining genomic stability, ensuring that cells either repair DNA damage efficiently or undergo apoptosis.
Activators of Wip1 are molecules or compounds that enhance the activity or expression of the Wip1 protein. These activators can function by promoting the enzymatic activity of Wip1, stabilizing its structure, or upregulating its expression at the transcriptional or translational levels. The presence of Wip1 activators can amplify the negative regulation of the p53 pathway, influencing the efficiency and outcome of DNA damage responses. Delving into the realm of Wip1 activators offers a microscopic view into the intricate network of signals that govern cellular responses to stress. As research continues to explore the vast landscape of cell signaling and genomic integrity, the role of Wip1 and its activators emerges as a focal point, emphasizing the delicate balance of molecular events that dictate cellular fate in the face of genomic insults.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin is a DNA-damaging agent that induces WIP1 expression via activation of the ATM-p53 pathway. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-FU can cause DNA damage and p53 activation, leading to increased WIP1 expression. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
An MDM2 antagonist that stabilizes p53, thereby potentially inducing WIP1 expression. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin induces DNA damage, which can lead to the activation of the p53 pathway and upregulation of WIP1. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide causes DNA damage and activates the p53 pathway, potentially increasing WIP1 expression. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D can induce DNA damage, leading to p53 activation and potential upregulation of WIP1. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin damages DNA, potentially leading to p53 activation and increased WIP1 expression. | ||||||
Temozolomide | 85622-93-1 | sc-203292 sc-203292A | 25 mg 100 mg | $91.00 $255.00 | 32 | |
This alkylating agent can cause DNA damage, leading to p53 pathway activation and potential upregulation of WIP1. | ||||||
SCH 900776 | 891494-63-6 | sc-364611 sc-364611A | 5 mg 10 mg | $255.00 $338.00 | ||
SCH 900776 is a selective inhibitor of Chk1. Inhibition of Chk1 can disrupt the DNA damage response, potentially leading to increased DNA damage and the subsequent activation of the p53 pathway. This may in turn upregulate WIP1 expression. | ||||||