VKORC1L1 Activators
VKORC1L1 Activators belong to a unique chemical class characterized by their ability to modulate the VKORC1L1 enzyme. VKORC1L1, which stands for Vitamin K epoxide reductase complex subunit 1-like 1, is an enzyme involved in the vitamin K cycle within the body. This chemical class of compounds acts as activators of VKORC1L1, thereby influencing the vitamin K-dependent processes that are crucial for the proper functioning of several physiological systems. These activators do not directly participate in these processes but rather facilitate them by enhancing the activity of VKORC1L1.
VKORC1L1 plays a pivotal role in the activation of vitamin K-dependent clotting factors and proteins. By activating VKORC1L1, compounds in the VKORC1L1 Activators class indirectly affect blood clotting, ensuring the synthesis of functional clotting factors. Additionally, these activators are thought to impact other vitamin K-dependent processes such as bone mineralization and arterial calcification. Although they do not directly intervene in these processes, their role in activating VKORC1L1 indirectly supports the formation of biologically active forms of vitamin K, which is essential for these physiological functions. Overall, VKORC1L1 Activators represent a fascinating class of compounds that modulate the enzymatic activity of VKORC1L1, with potential implications for various biological processes within the body.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Vitamin K1 | 84-80-0 | sc-280189 sc-280189A | 1 g 5 g | $81.00 $166.00 | ||
Vitamin K1 serves as a cofactor for VKORC1L1, which is essential for the carboxylation of glutamate residues in certain proteins, leading to their activation. By providing a source of reduced vitamin K, VKORC1L1 activity is enhanced as it recycles vitamin K epoxide back to its reduced form. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $71.00 $184.00 | 1 | |
Ubiquinone acts as an electron carrier within the electron transport chain and may indirectly enhance VKORC1L1 activity by maintaining a pool of reduced vitamin K, which is necessary for VKORC1L1's enzymatic function. | ||||||
Vitamin K3 | 58-27-5 | sc-205990B sc-205990 sc-205990A sc-205990C sc-205990D | 5 g 10 g 25 g 100 g 500 g | $26.00 $36.00 $47.00 $136.00 $455.00 | 3 | |
Menadione can be converted to active vitamin K2 in the body, which in turn serves as a cofactor for VKORC1L1, thereby potentially enhancing its activity in the carboxylation of specific glutamate residues in substrate proteins. | ||||||
Dicoumarol | 66-76-2 | sc-205647 sc-205647A | 500 mg 5 g | $20.00 $40.00 | 8 | |
Similar to warfarin, dicoumarol at low concentrations can have a potentiating effect on VKORC1L1 by causing a compensatory increase in the enzyme's activity to overcome the partial inhibition, thus enhancing the functional activity of VKORC1L1. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is known to alkalize intracellular compartments like lysosomes, which could indirectly affect VKORC1L1 by stabilizing its structure or enhancing its recycling, thus potentially leading to increased enzymatic activity. | ||||||
Glutathione, reduced | 70-18-8 | sc-29094 sc-29094A | 10 g 1 kg | $82.00 $2091.00 | 8 | |
Reduced glutathione can maintain the redox state of the cell, which is necessary for VKORC1L1 activity as the enzyme participates in a redox cycle during the vitamin K epoxide reduction process. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
N-Acetylcysteine, through its role as a precursor to glutathione, can indirectly enhance VKORC1L1 activity by contributing to the maintenance of a reducing environment. | ||||||
Vitamin K2 | 863-61-6 | sc-220385 sc-220385A | 250 mg 1 g | $146.00 $411.00 | 2 | |
Menaquinone-4 acts as a direct cofactor for VKORC1L1, thereby enhancing the enzyme's ability to catalyze the reduction of vitamin K epoxide, which is critical for the post-translational modification of vitamin K-dependent proteins. | ||||||
Hydroquinone | 123-31-9 | sc-204773 sc-204773A sc-204773B | 250 g 1 kg 5 kg | $37.00 $93.00 $400.00 | ||
Hydroquinone can act as a reducing agent, potentially contributing to the reduction of vitamin K epoxide, which may indirectly enhance VKORC1L1's enzymatic recycling of vitamin K. | ||||||