ProRS Activators
Prolyl-tRNA synthetase (ProRS), also known as PARS, is an enzyme that in humans is encoded by the EPRS gene. This enzyme belongs to the family of aminoacyl-tRNA synthetases (aaRSs), which play a critical role in protein synthesis.Aminoacyl-tRNA synthetases are responsible for charging tRNA molecules with their corresponding amino acids, a crucial step in the process of translation. ProRS specifically attaches the amino acid proline to its corresponding tRNA molecule (tRNA^Pro). This prolyl-tRNA then participates in the ribosome-mediated synthesis of a protein, by incorporating proline into the growing polypeptide chain at the appropriate positions as determined by the mRNA template.
In humans, ProRS is part of a bifunctional enzyme complex that also contains glutamyl-prolyl-tRNA synthetase. This bifunctional enzyme is unique among aaRSs and is linked by a sequence that is homologous to a region of the vesicular transport protein SecY.Beyond their classical role in protein synthesis, aminoacyl-tRNA synthetases, including ProRS, have been found to have additional functions in cellular processes such as cell signaling, RNA splicing, and the regulation of apoptosis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Halofuginone | 55837-20-2 | sc-507290 | 100 mg | $1775.00 | ||
An inhibitor of prolyl-tRNA synthetase, could indirectly affect ProRS by altering tRNA aminoacylation. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $41.00 $84.00 $275.00 | 127 | |
Inhibits eukaryotic translational elongation, potentially influencing ProRS function indirectly. | ||||||
Tetracycline | 60-54-8 | sc-205858 sc-205858A sc-205858B sc-205858C sc-205858D | 10 g 25 g 100 g 500 g 1 kg | $63.00 $94.00 $270.00 $417.00 $634.00 | 6 | |
An antibiotic that inhibits protein synthesis, could indirectly affect ProRS activity. | ||||||
Puromycin | 53-79-2 | sc-205821 sc-205821A | 10 mg 25 mg | $166.00 $322.00 | 436 | |
Causes premature chain termination during protein synthesis, potentially impacting ProRS indirectly. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $90.00 | 10 | |
Inhibits bacterial protein synthesis, could have indirect effects on ProRS activity. | ||||||
Erythromycin | 114-07-8 | sc-204742 sc-204742A sc-204742B sc-204742C | 5 g 25 g 100 g 1 kg | $57.00 $245.00 $831.00 $1331.00 | 4 | |
Binds to the 50S ribosomal subunit, indirectly affecting protein synthesis and potentially ProRS activity. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
A protein synthesis inhibitor that may indirectly affect ProRS by altering overall protein synthesis dynamics. | ||||||