Na+/K+-ATPase α2 Activators
Na+/K+-ATPase α2 activators constitute a class of chemicals with the ability to modulate the activity of the sodium-potassium pump isoform α2 (Na+/K+-ATPase α2). This isoform, a crucial component of cellular ion homeostasis, plays a fundamental role in maintaining the electrochemical gradients of sodium and potassium ions across the cell membrane. The direct activators identified, including Ouabain, Digoxin, Bufalin, Strophanthidin, Resibufogenin, Oleandrin, Proscillaridin A, Dihydroouabain, Palytoxin, Oubain, G-Strophanthin, and Marinobufagenin, selectively interact with Na+/K+-ATPase α2, inducing a conformational change that enhances its pump activity.
Ouabain, a classic cardiac glycoside, exemplifies the direct activation mechanism. Binding to the extracellular domain of Na+/K+-ATPase α2, Ouabain initiates a conformational change that promotes the enzyme's active state, facilitating the transport of sodium and potassium ions across the cell membrane. This isoform-specific interaction is shared among the identified activators, each demonstrating a unique chemical structure while targeting Na+/K+-ATPase α2. The physiological implications of Na+/K+-ATPase α2 activation extend across various cellular processes, including cell volume regulation, membrane potential maintenance, and signal transduction. The intricate interplay between these activators and Na+/K+-ATPase α2 underscores the isoform-specific regulation of cellular ion balance. Notably, these chemicals serve as valuable tools for probing the functional consequences of Na+/K+-ATPase α2 activation in diverse cellular contexts. Understanding the nuanced effects of these activators contributes to a comprehensive view of cellular ion homeostasis and opens avenues for exploring applications in a controlled and targeted manner.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ouabain-d3 (Major) | sc-478417 | 1 mg | $516.00 | |||
Ouabain, a cardiac glycoside, directly activates Na+/K+-ATPase α2 by binding to its extracellular domain. This binding induces a conformational change that promotes the enzyme's active state, leading to increased sodium and potassium ion transport across the cell membrane. | ||||||
12β-Hydroxydigitoxin | 20830-75-5 | sc-213604 sc-213604A | 1 g 5 g | $143.00 $694.00 | ||
12β-Hydroxydigitoxin, another cardiac glycoside, acts as a direct activator of Na+/K+-ATPase α2 by binding to its extracellular domain. This binding enhances the enzyme's pump activity, facilitating the transport of sodium and potassium ions across the cell membrane. | ||||||
Bufalin | 465-21-4 | sc-200136 sc-200136A sc-200136B sc-200136C | 10 mg 25 mg 50 mg 100 mg | $99.00 $204.00 $341.00 $544.00 | 5 | |
Bufalin, a cardiotonic steroid, can act as a direct activator of Na+/K+-ATPase α2. By binding to the extracellular domain of the enzyme, Bufalin induces a conformational change that enhances its pump activity, facilitating the transport of sodium and potassium ions across the cell membrane. | ||||||
Strophanthidin | 66-28-4 | sc-215914 sc-215914A | 250 mg 1 g | $215.00 $692.00 | 2 | |
Strophanthidin, a cardiac glycoside, acts as a direct activator of Na+/K+-ATPase α2 by binding to its extracellular domain. This binding induces a conformational change that enhances the pump activity of the enzyme, facilitating the transport of sodium and potassium ions across the cell membrane. | ||||||
Resibufogenin | 465-39-4 | sc-202788 | 10 mg | $321.00 | 2 | |
Resibufogenin, a cardiotonic steroid, can act as a direct activator of Na+/K+-ATPase α2. By binding to the extracellular domain of the enzyme, Resibufogenin induces a conformational change that enhances its pump activity, facilitating the transport of sodium and potassium ions across the cell membrane. | ||||||
Dihydroouabain | 1183-35-3 | sc-252720 | 50 mg | $468.00 | ||
Dihydroouabain, a derivative of Ouabain, acts as a direct activator of Na+/K+-ATPase α2 by binding to its extracellular domain. This binding induces a conformational change that enhances the pump activity of the enzyme, facilitating the transport of sodium and potassium ions across the cell membrane. | ||||||
Ouabain Octahydrate | 11018-89-6 | sc-201548 sc-201548A | 1 g 5 g | $194.00 $734.00 | 11 | |
Oubain, a derivative of Ouabain, acts as a direct activator of Na+/K+-ATPase α2 by binding to its extracellular domain. This binding induces a conformational change that enhances the pump activity of the enzyme, facilitating the transport of sodium and potassium ions across the cell membrane. | ||||||