Molecular structure of Strophanthidin, CAS Number: 66-28-4
Strophanthidin (CAS 66-28-4)
See product citations (2)
Alternate Names:
3β,5,14-Trihydroxy-19-oxo-5β,20(22)-cardenolide; Cymarigenen; K-Strophanthidin
Application:
Strophanthidin is a cardiotonic steroid that elevates the activity of Na+/K+-ATPase in cardiac myocytes
CAS Number:
66-28-4
Purity:
≥90%
Molecular Weight:
404.50
Molecular Formula:
C23H32O6
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Strophanthidin, a potent cardiotonic glycoside, is obtained from the seeds of Strophanthus gratus and other species within the Strophanthus genus. It has been discovered to possess cardiotonic abilities, increasing the contraction force of the heart muscle, in extensive laboratory studies. It has also shown anti-inflammatory properties. Strophanthidin operates by attaching to specific receptors on cell surfaces, which triggers a series of events within the cell. These events activate certain enzymes, leading to the production of compounds that can exert various effects on the body. For instance, the activation of certain enzymes can lead to compounds that enhance the heart muscle′s contraction force. Similarly, certain enzymes′ activation can lead to compounds that can alleviate inflammation.
Strophanthidin (CAS 66-28-4) References
- Strophanthidin-induced gain of Ca2+ occurs during diastole and not systole in guinea-pig ventricular myocytes. | Bennett, DL., et al. 1999. Pflugers Arch. 437: 731-6. PMID: 10087151
- Effect of nitric oxide on strophanthidin-induced ventricular tachycardia. | Chen, YJ., et al. 2001. Pharmacology. 62: 213-7. PMID: 11359997
- Inotropic action of acetyl-strophanthidin, strophanthidin, and tryptamine-strophanthidin. | GREINER, T. and REILLY, J. 1952. Proc Soc Exp Biol Med. 81: 141-4. PMID: 13047340
- EFFECTS OF EXTERNAL POTASSIUM AND STROPHANTHIDIN ON SODIUM FLUXES IN FROG STRIATED MUSCLE. | HOROWICZ, P. and GERBER, CJ. 1965. J Gen Physiol. 48: 489-514. PMID: 14284780
- Mechanistic insight into the functional and toxic effects of Strophanthidin in the failing human myocardium. | von Lewinski, D., et al. 2007. Eur J Heart Fail. 9: 1086-94. PMID: 17956764
- The effect of strophanthidin on action potential, calcium current and contraction in isolated guinea-pig ventricular myocytes. | Levi, AJ. 1991. J Physiol. 443: 1-23. PMID: 1822522
- On the mechanism of the positive inotropy of low concentrations of strophanthidin. | Aceto, E. and Vassalle, M. 1991. J Pharmacol Exp Ther. 259: 182-9. PMID: 1920115
- Effects of strophanthidin on the slow inward current in guinea-pig isolated ventricular myocytes. | Yang, L. and Vassalle, M. 1990. Clin Exp Pharmacol Physiol. 17: 105-20. PMID: 2328542
- On the mechanism of the different sensitivity of Purkinje and myocardial fibers to strophanthidin. | Iacono, G. and Vassalle, M. 1990. J Pharmacol Exp Ther. 253: 1-12. PMID: 2329497
- Strophanthidin and potassium on intracellular sodium activity in sheep heart. | Gretler, DD. 1985. J Mol Cell Cardiol. 17: 1105-13. PMID: 3001322
- Strophanthidin inotropy in cardiac Purkinje fibers under conditions that vary cellular sodium or calcium. | Li, T., et al. 1986. Can J Physiol Pharmacol. 64: 1385-94. PMID: 3791040
- Role of sodium in strophanthidin toxicity of Purkinje fibers. | Lin, CI. and Vassalle, M. 1978. Am J Physiol. 234: H477-86. PMID: 645886
- Effect of strophanthidin on intracellular Na ion activity and twitch tension of constantly driven canine cardiac Purkinje fibers. | Lee, CO. and Dagostino, M. 1982. Biophys J. 40: 185-98. PMID: 7183333
- Actions of the digitalis analogue strophanthidin on action potentials and L-type calcium current in single cells isolated from the rabbit atrioventricular node. | Hancox, JC. and Levi, AJ. 1996. Br J Pharmacol. 118: 1447-54. PMID: 8832071
- Comparative effects of strophanthidin in tilapia and human heart tissues. | Lin, TC., et al. 1995. Chin J Physiol. 38: 177-84. PMID: 8846727
Inhibitor of:
ATP1AL1, Na+/K+-ATPase α1, Na+/K+-ATPase β2, Neurensin-2, NKAIN2, sodium/potassium-ATPase α1, and sodium/potassium-ATPase β1.Activator of:
FXYD7, Na+/K+-ATPase α2, Na+/K+-ATPase α4, and sodium/potassium-ATPase α3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Strophanthidin, 250 mg | sc-215914 | 250 mg | $215.00 | |||
Strophanthidin, 1 g | sc-215914A | 1 g | $692.00 |