ICMT Activators
ICMT activators are compounds or molecules that have the potential to enhance the activity of the enzyme Isoprenylcysteine Carboxyl Methyltransferase (ICMT). ICMT plays a crucial role in post-translational modification processes, specifically in the methylation of isoprenylated cysteine residues of proteins. This methylation is essential for the proper function and membrane localization of various proteins involved in signaling pathways, including Ras and other small GTPases.
ICMT activators function by promoting the enzymatic activity of ICMT, ultimately leading to an increased methylation of target proteins. This activation can occur through several mechanisms. For instance, some activators may enhance the availability of the methyl donor S-adenosylmethionine (SAM), which is essential for ICMT's methyltransferase activity. Others may directly interact with ICMT, stabilizing its active conformation or increasing its affinity for substrates. Additionally, certain compounds may indirectly activate ICMT by modulating the prenylation status of proteins, which are substrates of ICMT. By influencing the availability of these substrates, ICMT activators can impact various cellular processes, including signal transduction and protein trafficking.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tipifarnib | 192185-72-1 | sc-364637 | 10 mg | $720.00 | ||
Tipifarnib is an orally active FTI that inhibits the prenylation of proteins, indirectly affecting the substrates available for ICMT methylation. | ||||||
GGTI-2133 | 1217480-14-2 | sc-221668 sc-221668A | 1 mg 5 mg | $219.00 $632.00 | 2 | |
GGTI-2133 is a GGTI that targets geranylgeranyltransferase, impacting the prenylation of proteins before ICMT methylation. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
SAM is a methyl donor that enhances the availability of methyl groups in cells, potentially influencing ICMT activity indirectly by affecting its substrate pool. | ||||||
Farnesyl thiosalicylic acid | 162520-00-5 | sc-205322 sc-205322A | 1 mg 5 mg | $61.00 $82.00 | 15 | |
Salirasib inhibits Ras activation, indirectly affecting ICMT activity as ICMT is involved in Ras methylation. | ||||||
Adenosine, periodate oxidized | 34240-05-6 | sc-214510 sc-214510A | 25 mg 100 mg | $119.00 $364.00 | ||
Adenosine Dialdehyde is a general methyltransferase inhibitor that may impact ICMT activity. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts the trafficking of prenylated proteins within cells, potentially impacting the availability of substrates for ICMT. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 inhibits the proteasome, which can indirectly influence ICMT substrates' stability by affecting protein degradation pathways. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an autophagy inducer that can impact the degradation of prenylated proteins, indirectly influencing ICMT substrates. | ||||||