Fibulin-1 Activators
Fibulin-1, a multifunctional glycoprotein found in the extracellular matrix (ECM), plays critical roles in various biological processes essential for tissue development, maintenance, and homeostasis. Functionally, Fibulin-1 serves as a structural component of the ECM, contributing to its stability and elasticity. It interacts with other ECM molecules such as fibrillin and elastin, forming intricate networks that provide structural support to tissues. Additionally, Fibulin-1 is involved in cell adhesion, migration, and signaling, mediating communication between cells and their microenvironment. Through its interactions with integrins and growth factors, Fibulin-1 modulates signaling pathways such as TGF-β and Wnt, regulating cellular processes like proliferation and differentiation.
Activation of Fibulin-1 involves various mechanisms that enhance its functional activity and promote its roles in tissue homeostasis and repair. One such mechanism is post-translational modification, including glycosylation and proteolytic processing, which can modulate Fibulin-1's interactions with other ECM components and cell surface receptors. Additionally, extracellular cues such as mechanical forces or biochemical signals from neighboring cells can stimulate Fibulin-1 expression and secretion. Activation of signaling pathways associated with tissue remodeling, such as TGF-β and Notch, can also induce Fibulin-1 production, facilitating ECM remodeling and cell behavior. Overall, the activation of Fibulin-1 orchestrates a complex network of molecular events that contribute to tissue integrity and function, highlighting its importance in physiological processes and implications in pathological conditions.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a natural compound that activates adenylate cyclase, leading to increased cAMP levels. Elevated cAMP can modulate various cellular processes, potentially impacting pathways related to Fibulin-1 and influencing its activation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate (EGCG) is a polyphenol found in green tea. It has been reported to modulate Wnt/β-catenin signaling, a pathway associated with Fibulin-1 regulation. The activation of Wnt/β-catenin by EGCG can indirectly contribute to Fibulin-1 activation. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR (5-Aminoimidazole-4-carboxamide ribonucleotide) is an activator of AMP-activated protein kinase (AMPK). Activation of AMPK by AICAR can influence cellular energy balance and signaling pathways, potentially impacting Fibulin-1 activation through AMPK-mediated pathways. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane is a compound found in cruciferous vegetables. It has been shown to activate Nrf2, a transcription factor involved in cellular stress response. The activation of Nrf2 by sulforaphane may modulate pathways related to Fibulin-1 and contribute to its activation. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a selective inhibitor of Rho-associated protein kinase (ROCK), and its inhibition of ROCK can activate the Rho/ROCK signaling pathway. Activation of Rho/ROCK may influence cellular processes associated with Fibulin-1 and contribute to its activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a natural polyphenol with reported effects on SIRT1, a NAD+-dependent deacetylase. Activation of SIRT1 by resveratrol can impact various cellular pathways, potentially influencing Fibulin-1 activation through SIRT1-mediated processes. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $184.00 $741.00 $1076.00 $3417.00 $5304.00 | 23 | |
A769662 is an activator of AMP-activated protein kinase (AMPK). Activation of AMPK by A769662 can modulate cellular energy balance and signaling pathways, potentially impacting Fibulin-1 activation through AMPK-mediated processes. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 (PGE2) is a lipid mediator with diverse physiological effects. It can activate EP2 and EP4 receptors, leading to increased cAMP levels. The elevation of cAMP may modulate cellular processes associated with Fibulin-1, contributing to its activation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that induces intracellular calcium release. Increased intracellular calcium levels can activate various signaling pathways, potentially impacting Fibulin-1 activation through calcium-dependent processes. | ||||||
GSK1016790A | 942206-85-1 | sc-255193 | 10 mg | $265.00 | 6 | |
GSK1016790A is an agonist of the free fatty acid receptor 4 (FFA4). Activation of FFA4 by GSK1016790A can modulate intracellular signaling pathways, potentially influencing cellular processes associated with Fibulin-1 and contributing to its activation. | ||||||