CSAP Activators
CSAP activators are compounds primarily characterized by their influence on cell cycle regulators, microtubule dynamics, and kinase activity. Within this class, compounds such as Roscovitine, Olomoucine, and Purvalanol A are notable for their role as cyclin-dependent kinase inhibitors, which indirectly promote the stabilization and function of CSAP in maintaining centrosome cohesion and facilitating proper cilia formation. These molecules achieve this by altering the activity of proteins that interact with centrosomal structures, thereby creating a cellular state that necessitates the involvement of CSAP to preserve centrosome integrity and ensure accurate cell division.
Moreover, compounds like Demecolcine, which perturbs the microtubule network, engender a cellular environment that may lead to enhanced CSAP activity in an attempt to compensate for the resulting centrosome fragmentation and spindle assembly defects. Kinesin inhibitors such as Monastrol and S-Trityl-L-cysteine disrupt spindle dynamics and thus may elevate the functional requirements of CSAP in spindle stabilization. Other components of this class, including kinase inhibitors like ZM447439, BI 2536, and Harmine, disrupt specific phosphorylation events that are crucial for centrosome maturation, separation, and function. The inhibition of these kinases can necessitate greater CSAP activity to uphold the structural and operational integrity of the centrosome and associated structures.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
A cyclin-dependent kinase inhibitor that stabilizes centrosomal integrity, potentially enhancing CSAP function required for proper centrosome cohesion and cilia formation. | ||||||
Olomoucine | 101622-51-9 | sc-3509 sc-3509A | 5 mg 25 mg | $72.00 $274.00 | 12 | |
Another cyclin-dependent kinase inhibitor that can maintain centrosome cohesion, potentially increasing the need for CSAP's role in centrosome stability. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
An adenylate cyclase activator that raises cAMP levels, which can modulate various centrosomal proteins and possibly enhance CSAP activity in centriole and cilia dynamics. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
An Aurora kinase inhibitor that disrupts centrosome maturation and separation, possibly requiring increased CSAP activity to maintain centrosome function. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
A kinesin Eg5 inhibitor that disrupts spindle dynamics, potentially increasing the role of CSAP in spindle assembly and stabilization. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $32.00 $66.00 | 6 | |
A kinesin Eg5 inhibitor, similar to Monastrol, that can lead to spindle apparatus abnormalities, potentially necessitating increased CSAP activity for spindle fidelity. | ||||||
Colcemid | 477-30-5 | sc-202550A sc-202550 sc-202550B sc-202550C sc-202550D sc-202550E | 1 mg 5 mg 10 mg 50 mg 100 mg 500 mg | $68.00 $162.00 $318.00 $947.00 $1893.00 $6840.00 | 7 | |
A microtubule depolymerizing agent that affects spindle formation, potentially triggering mechanisms that enhance the role of CSAP in spindle assembly. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $72.00 $297.00 | 4 | |
A potent cyclin-dependent kinase inhibitor that may enhance CSAP activity by stabilizing structures associated with the centrosome and cilia. | ||||||
Harmine | 442-51-3 | sc-202644 sc-202644A sc-202644B sc-202644C sc-202644D sc-202644E sc-202644F | 250 mg 500 mg 1 g 10 g 50 g 100 g 500 g | $53.00 $104.00 $126.00 $551.00 $1467.00 $2611.00 $11455.00 | 2 | |
A dual-specificity tyrosine phosphorylation-regulated kinase inhibitor that can affect centrosome dynamics, potentially implicating CSAP in compensatory mechanisms. | ||||||
BI6727 | 755038-65-4 | sc-364432 sc-364432A sc-364432B sc-364432C sc-364432D | 5 mg 50 mg 100 mg 500 mg 1 g | $150.00 $1050.00 $1665.00 $3329.00 $4382.00 | 1 | |
A Plk1 inhibitor that disrupts centrosome function and spindle formation, potentially leading to increased CSAP activity for maintaining centrosome integrity. | ||||||