20S Proteasome α7 Activators
The 20S Proteasome α7 is a critical part of the proteasome complex, which plays a central role in protein degradation. Chemicals such as MG132 and Lactacystin, which are proteasome inhibitors, can indirectly enhance the functional activity of 20S Proteasome α7. Inhibition of the proteasome complex leads to an accumulation of proteins that require degradation. This accumulation can increase the demand for proteasome function, potentially enhancing the activity of the 20S Proteasome α7, which is integral to the proteasome complex.
Another group of chemicals that can potentially enhance the functional activity of the 20S Proteasome α7 are those that induce oxidative stress. Oxidative stress can lead to protein damage, increasing the need for protein degradation by the proteasome. Chemicals such as Oxidized Glutathione (GSSG), N-Acetyl Cysteine (NAC), Tert-Butylhydroquinone (tBHQ), Sulforaphane, Curcumin, and Resveratrol can induce oxidative stress. The increase in damaged proteins requiring degradation can potentially result in enhanced activity of the 20S Proteasome α7, given its role in the proteasome complex.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor that can indirectly enhance 20S Proteasome α7 activity by leading to an accumulation of proteins that require degradation, potentially increasing the demand for proteasome function | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
Another proteasome inhibitor that can similarly increase the demand for protein degradation and thereby potentially enhance 20S Proteasome α7 activity | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Lactacystin is a potent inhibitor of the proteasome, and its administration can potentially enhance the functional activity of 20S Proteasome α7 by increasing demand for protein degradation | ||||||
Glutathione, oxidized | 27025-41-8 | sc-29093B sc-29093A sc-29093 | 250 mg 1 g 5 g | $58.00 $84.00 $275.00 | 3 | |
In conditions of oxidative stress, GSSG levels rise, which can lead to protein damage and an increased need for proteasomal activity | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
NAC is a precursor to glutathione and can potentially increase proteasomal demand under conditions of oxidative stress | ||||||
t-Butylhydroquinone | 1948-33-0 | sc-202825 | 10 g | $67.00 | 4 | |
tBHQ can induce oxidative stress and potentially enhance 20S Proteasome α7 activity by increasing the pool of damaged proteins | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane can induce oxidative stress and potentially enhance 20S Proteasome α7 activity by increasing the pool of proteins requiring degradation | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can induce oxidative stress, which can potentially lead to an increased demand for proteasomal activity | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can induce oxidative stress and potentially enhance 20S Proteasome α7 activity by increasing the pool of proteins requiring degradation | ||||||