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ZAG (Zn-α2-glycoprotein, also designated Zn-α2-gp) is a soluble, secreted protein found in serum and other body fluids (such as cerebrospinal fluid, blood plasma, urine and sweat). ZAG has a tendency to precipitate with zinc salts, has electrophoretic mobility in the region of the two globulins, and has 18% carbohydrate content. A member of the immunoglobulin superfamily, ZAG has a high degree of sequence similarity to class-I major histocompatibility complex (MHC) antigens. The ZAG structure includes a large groove analogous to class I MHC peptide binding grooves. The crystal structure of ZAG resembles a class I MHC heavy chain but does not bind the class I light chain β-2-Microglobulin, unlike other MHC related proteins. ZAG stimulates lipid degradation in adipocytes and its overexpression causes the extensive fat losses associated with some advanced cancers.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps ZAG (E-3) | sc-390772 | 200 µg/ml | $316.00 |