ZAG Antibody (1E2): sc-21720

ZAG Antibody (1E2) is a mouse monoclonal IgG1 antibody that detects ZAG (Zn-α2-glycoprotein) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). ZAG is a soluble, secreted protein predominantly found in serum and various body fluids, including cerebrospinal fluid, blood plasma, urine, and sweat. ZAG (1E2) antibody helps researchers study a protein that plays a crucial role in lipid metabolism by stimulating lipid degradation in adipocytes, which is significant for maintaining energy homeostasis and regulating body weight. ZAG overexpression has been linked to extensive fat losses observed in certain advanced cancers, highlighting ZAG′s potential as a biomarker for cancer cachexia. The structure of ZAG features a large groove similar to the peptide binding grooves of class I major histocompatibility complex (MHC) proteins, although ZAG does not bind the class I light chain β-2-Microglobulin. This unique structural characteristic may influence ZAG′s interactions and functions within the immune system and metabolic pathways. Anti-ZAG antibody (1E2) serves as an essential tool for researchers investigating ZAG′s roles in various physiological and pathological contexts.

The preferred ZAG antibody is ZAG Antibody (1D4): sc-13585.