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The TSG6 gene is transcribed in normal fibroblasts and activated by binding of the cytokines TNFα and IL-1 at AP-1 and NF-IL6 sites in its promoter. TSG-6 is a glycoprotein and a member of the hyaluronan-binding protein family, which includes cartilage link protein, proteoglycan core protein and the adhesion receptor CD44. TSG-6 is highly homologous to CD44, particularly in the hyaluronic acid-binding domain. TSG-6 is found in TNF-treated cells; its expression is rapidly activated by TNFα, IL-1 and lipopolysaccharide in normal fibroblasts, peripheral blood mononuclear cells, synovial cells and chondrocytes. The presence of TSG-6 in synovial fluid suggests a possible role in rheumatoid arthritis. TSG-6 forms a stable complex with components of the serine protease inhibitor, inter-α-inhibitor (IαI)). TSG-6 potentiates the inhibitory effect of lαl on the protease activity of plasmin. Through their cooperative inhibitory effect on plasmin, TSG-6 and lαl can modulate the protease network and thus inhibit inflammation.
Informations pour la commande
Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps TSG-6 (D-4) | sc-398307 | 200 µg/ml | $316.00 | |||
TSG-6 (D-4): m-IgG Fc BP-HRP Kit | sc-540928 | 200 µg Ab; 10 µg BP | $354.00 | |||
TSG-6 (D-4): m-IgG1 BP-HRP Kit | sc-542469 | 200 µg Ab; 20 µg BP | $354.00 | |||
TSG-6 (D-4) peptide neutralisant | sc-398307 P | 100 µg/0.5 ml | $68.00 |