Anticorps TRC8 (YB-16): sc-101115
- L'Anticorps TRC8 (YB-16) est un monoclonal de souris IgG1 (chaîne légère kappa) fourni en 100 µg/ml
- dirigé contre la TRC8 recombinante d'origine human
- recommandé pour la détection de TRC8 d'origine human par WB, IP, IF, IHC(P) et ELISA
- Nous testons actuellement encore nos anticorps secondaires pour trouver la meilleure protéine de liaison pour cet anticorps primaire TRC8 (YB-16). Veuillez nous contacter si vous avez des questions concernant les réactifs de détection secondaire appropriés.
ACCÈS RAPIDE AUX LIENS
TRC8 (translocation in renal carcinoma on chromosome 8), also known as RNF139 (ring finger protein 139), RCA1 or HRCA1 (hereditary renal cancer associated 1), is a multi-pass membrane protein that is predominantly expressed in testis, adrenal gland and placenta and is expressed at lower levels in liver, skeletal muscle, pancreas, kidney, brain, heart and lung. Localizing to the endoplasmic reticulum (ER), TRC8 contains ten transmembrane segments, a sterol-sensing domain and one RING-type zinc finger and may function as a ubiquitin ligase and signaling receptor. TRC8 physically interacts with VHL (Von Hippel Lindau disease tumor suppressor), and the inhibition of either of these proteins leads to the same ventral midline defect. Disruption of the TRC8 gene, caused by the 3;8 chromosomal translocation, is associated with hereditary renal cell carcinoma (RCC), suggesting that TRC8 is a potential tumor suppressor for RCC. Further supporting its role as a tumor suppressor, TRC8 mediates the induction of G2/M phase arrest, increased apoptosis and decreased DNA synthesis.
Informations pour la commande
| Nom du produit | Ref. Catalogue | COND. | Prix HT | QTÉ | Favoris | |
Anticorps TRC8 (YB-16) | sc-101115 | 100 µg/ml | $333.00 |