STELLA Antibody (D-5): sc-376862
- STELLA Antibody (D-5) is a mouse monoclonal IgG1 κ STELLA antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 1-159 representing full length STELLA of human origin
- STELLA Antibody (D-5) is recommended for detection of STELLA of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-STELLA Antibody (D-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for STELLA Antibody (D-5) for WB and IHC(P) applications. This reagent is now offered in a bundle with STELLA Antibody (D-5) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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STELLA Antibody (D-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects STELLA protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). STELLA (D-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. STELLA protein, also known as Dppa3 and Pcg7, is a crucial member of the developmental pluripotency-associated protein family, playing a significant role in embryonic germ cell development. STELLA protein is predominantly expressed in the fetal ovary, with lower levels found in the testis and thymus, highlighting STELLA′s importance in germ cell differentiation and as a maternal factor that regulates early embryogenesis. STELLA protein is also implicated in tumor biology, as STELLA is overexpressed in testicular germ cell tumors, suggesting a potential role in tumor formation and making STELLA protein a promising candidate for early cancer detection. STELLA protein′s ability to interact with specific transcription factors and signaling pathways further underscores STELLA′s significance in both normal development and pathological conditions, making anti-STELLA antibody (D-5) an essential tool for researchers studying embryonic development and cancer biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
STELLA Antibody (D-5) References:
- A molecular programme for the specification of germ cell fate in mice. | Saitou, M., et al. 2002. Nature. 418: 293-300. PMID: 12124616
- Stella is a maternal effect gene required for normal early development in mice. | Payer, B., et al. 2003. Curr Biol. 13: 2110-7. PMID: 14654002
- Dppa3 is a marker of pluripotency and has a human homologue that is expressed in germ cell tumours. | Bowles, J., et al. 2003. Cytogenet Genome Res. 101: 261-5. PMID: 14684992
- Dppa3 / Pgc7 / stella is a maternal factor and is not required for germ cell specification in mice. | Bortvin, A., et al. 2004. BMC Dev Biol. 4: 2. PMID: 15018652
- Adult tissue-specific expression of a Dppa3-derived retrogene represents a postnatal transcript of pluripotent cell origin. | Elliman, SJ., et al. 2006. J Biol Chem. 281: 16-9. PMID: 16291741
- Dazl deficiency leads to embryonic arrest of germ cell development in XY C57BL/6 mice. | Lin, Y. and Page, DC. 2005. Dev Biol. 288: 309-16. PMID: 16310179
- IFITM/Mil/fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion. | Tanaka, SS., et al. 2005. Dev Cell. 9: 745-56. PMID: 16326387
- Diverse epigenetic profile of novel human embryonic stem cell lines. | Lagarkova, MA., et al. 2006. Cell Cycle. 5: 416-20. PMID: 16479162
- Gene expression dynamics during germline specification in mice identified by quantitative single-cell gene expression profiling. | Yabuta, Y., et al. 2006. Biol Reprod. 75: 705-16. PMID: 16870942
- Stella modulates transcriptional and endogenous retrovirus programs during maternal-to-zygotic transition. | Huang, Y., et al. 2017. Elife. 6: PMID: 28323615
- Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1. | Li, Y., et al. 2018. Nature. 564: 136-140. PMID: 30487604
- Stella Regulates the Development of Female Germline Stem Cells by Modulating Chromatin Structure and DNA Methylation. | Hou, C., et al. 2022. Int J Biol Sci. 18: 3006-3018. PMID: 35541912
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
STELLA Antibody (D-5) | sc-376862 | 200 µg/ml | $322.00 | |||
STELLA Antibody (D-5): m-IgGκ BP-HRP Bundle | sc-523120 | 200 µg Ab, 40 µg BP | $361.00 | |||
STELLA Antibody (D-5) AC | sc-376862 AC | 500 µg/ml, 25% agarose | $424.00 | |||
STELLA Antibody (D-5) HRP | sc-376862 HRP | 200 µg/ml | $322.00 | |||
STELLA Antibody (D-5) FITC | sc-376862 FITC | 200 µg/ml | $336.00 | |||
STELLA Antibody (D-5) PE | sc-376862 PE | 200 µg/ml | $349.00 | |||
STELLA Antibody (D-5) Alexa Fluor® 488 | sc-376862 AF488 | 200 µg/ml | $364.00 | |||
STELLA Antibody (D-5) Alexa Fluor® 546 | sc-376862 AF546 | 200 µg/ml | $364.00 | |||
STELLA Antibody (D-5) Alexa Fluor® 594 | sc-376862 AF594 | 200 µg/ml | $364.00 | |||
STELLA Antibody (D-5) Alexa Fluor® 647 | sc-376862 AF647 | 200 µg/ml | $364.00 | |||
STELLA Antibody (D-5) Alexa Fluor® 680 | sc-376862 AF680 | 200 µg/ml | $364.00 | |||
STELLA Antibody (D-5) Alexa Fluor® 790 | sc-376862 AF790 | 200 µg/ml | $364.00 |