Shc Antibody (B-9): sc-393717
- Shc Antibody (B-9) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 554-585 at the C-terminus of Shc of human origin
- recommended for detection of Shc p66, p52 and p46, and N-Shc p64 and p52 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- See Shc (PG-797): sc-967 for Shc antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Shc Antibody (B-9) for WB applications. These reagents are now offered in bundles with Shc Antibody (B-9) (see ordering information below).
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Shc Antibody (B-9) is a mouse monoclonal IgG2b antibody that detects Shc in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Shc antibody (B-9) plays a crucial role in studying signaling pathways activated by growth factor-triggered protein tyrosine kinase receptors, which are essential for cellular responses such as proliferation and differentiation. Shc (B-9) antibody enables detection of Shc primarily in the cytoplasm, where Shc acts as an adapter linking activated receptors to downstream signaling molecules, facilitating signal transmission to the nucleus. This cytoplasmic localization allows Shc to rapidly respond to receptor activation and initiate signaling cascades leading to mitogenic responses. Additionally, Shc interacts with various proteins, including adapter protein GRB2 and guanine nucleotide exchange factor Sos, which are critical for linking the insulin receptor to the Ras signaling pathway. Formation of these protein complexes underscores Shc′s importance in mediating insulin signaling and highlights Shc′s role in metabolic regulation. Shc monoclonal antibody (B-9) serves as an invaluable tool for researchers studying the intricate signaling networks that govern cellular behavior.
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Shc Antibody (B-9) References:
- The functional significance of Shc in insulin signaling as a substrate of the insulin receptor. | Sasaoka, T. and Kobayashi, M. 2000. Endocr J. 47: 373-81. PMID: 11075717
- Evolution of Shc functions from nematode to human. | Luzi, L., et al. 2000. Curr Opin Genet Dev. 10: 668-74. PMID: 11088019
- Signaling via Shc family adapter proteins. | Ravichandran, KS. 2001. Oncogene. 20: 6322-30. PMID: 11607835
- p66 Shc as the engine of vascular aging. | Paneni, F. and Cosentino, F. 2012. Curr Vasc Pharmacol. 10: 697-9. PMID: 23259557
- The p66(Shc) gene paves the way for healthspan: evolutionary and mechanistic perspectives. | Berry, A. and Cirulli, F. 2013. Neurosci Biobehav Rev. 37: 790-802. PMID: 23524280
- let-7-repressesed Shc translation delays replicative senescence. | Xu, F., et al. 2014. Aging Cell. 13: 185-92. PMID: 24165399
- P66Shc-SIRT1 Regulation of Oxidative Stress Protects Against Cardio-cerebral Vascular Disease. | Kong, X., et al. 2017. Mol Neurobiol. 54: 5277-5285. PMID: 27578018
- Insights into the Shc Family of Adaptor Proteins. | Ahmed, SBM. and Prigent, SA. 2017. J Mol Signal. 12: 2. PMID: 30210578
- The longevity protein p66Shc is required for neonatal heart regeneration. | Huang, C., et al. 2023. J Mol Cell Cardiol. 177: 21-27. PMID: 36827872
- Not all Shc's roads lead to Ras. | Bonfini, L., et al. 1996. Trends Biochem Sci. 21: 257-61. PMID: 8755247
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Shc Antibody (B-9) | sc-393717 | 200 µg/ml | $322.00 | |||
Shc Antibody (B-9): m-IgG Fc BP-HRP Bundle | sc-538292 | 200 µg Ab; 10 µg BP | $361.00 | |||
Shc Antibody (B-9): m-IgGκ BP-HRP Bundle | sc-535873 | 200 µg Ab; 40 µg BP | $361.00 | |||
Shc Antibody (B-9): m-IgG2b BP-HRP Bundle | sc-549934 | 200 µg Ab; 10 µg BP | $361.00 | |||
Shc (B-9) Neutralizing Peptide | sc-393717 P | 100 µg/0.5 ml | $69.00 |